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Literature summary for 3.4.21.45 extracted from

  • Cunnion, K.M.; Hair, P.S.; Buescher, E.S.
    Cleavage of complement C3b to iC3b on the surface of Staphylococcus aureus is mediated by serum complement factor I (2004), Infect. Immun., 72, 2858-2863.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine the process of factor I binding is a potential target for therapeutic intervention to facilitate host defense against Staphylococcus aureus Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3b + H2O Homo sapiens the complement C3 fragments C3b and iC3b appear on the surface of several virulent Staphylococcus aureus strains of capsule polysaccharide type 5 and 8. Factor I mediates the cleavage of C3b to iC3b on the surface of Staphylococcus aureus and appears to be able to function without the serum cofactor, factor H complement component iC3b + ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
blood serum
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3b + H2O cleavage does not require presence of factor H Homo sapiens complement component iC3b + ?
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 ?
complement component C3b + H2O the complement C3 fragments C3b and iC3b appear on the surface of several virulent Staphylococcus aureus strains of capsule polysaccharide type 5 and 8. Factor I mediates the cleavage of C3b to iC3b on the surface of Staphylococcus aureus and appears to be able to function without the serum cofactor, factor H Homo sapiens complement component iC3b + ?
-
 ?