Cloned (Comment) | Organism |
---|---|
expressed in Chinese hamster ovary cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
complex between the CUB1-EGF-CUB2 domains of C1r and C1s, sitting drop vapor diffusion method, in imidazole buffer at pH 8.0 with PEG 8000 as the precipitant | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C1s + H2O | Homo sapiens | - |
activated complement component C1s + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00736 | - |
- |
Purification (Comment) | Organism |
---|---|
nickel-Sepharose affinity column chromatography and Superdex 200 gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C1s + H2O | - |
Homo sapiens | activated complement component C1s + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 90000, component C1r, calculated from amino acid sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
multiprotein complex C1 | the multiprotein complex C1 is formed from the recognition subcomponent C1q and a tetramer of proteases C1r2C1s2 | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | multiprotein complex C1 triggers the destruction of invading pathogens via lysis or by stimulation of innate and adaptive immune processes | Homo sapiens |