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Literature summary for 3.4.21.39 extracted from
- Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse - High specificity indicates high substrate selectivity (2008), Mol. Immunol., 45, 2548-2558.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NAT agarose bead chromatography, heparin affinity chromatography, and gel filtration | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BMMC cell | - |
Mus musculus | - |
| mast cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| atrial natriuretic peptide clearance receptor + H2O | potential substrate | Mus musculus | ? | - |
? |  |
| cadherin-10 + H2O | potential substrate | Mus musculus | ? | - |
? | |
| cadherin-13 + H2O | potential substrate | Mus musculus | ? | - |
? | |
| collagen alpha-1(VI) chain + H2O | potential substrate | Mus musculus | ? | - |
? | |
| collagen alpha-1(XII) chain + H2O | potential substrate | Mus musculus | ? | - |
? | |
| desmocollin-3 + H2O | potential substrate | Mus musculus | ? | - |
? | |
| integrin alpha-11 + H2O | potential substrate | Mus musculus | ? | - |
? | |
| integrin alpha-3 + H2O | potential substrate | Mus musculus | ? | - |
? | |
| integrin alpha-7 + H2O | potential substrate | Mus musculus | ? | - |
? | |
| laminin alpha-3 chain + H2O | potential substrate | Mus musculus | ? | - |
? | |
| laminin alpha-4 chain + H2O | potential substrate | Mus musculus | ? | - |
? | |
| laminin alpha-5 chain + H2O | potential substrate | Mus musculus | ? | - |
? | |
| laminin gamma-1 chain + H2O | potential substrate | Mus musculus | ? | - |
? | |
| matrix metalloprotease 8 + H2O | potential substrate | Mus musculus | ? | - |
? | |
| methoxy-succinyl-Arg-Ala-Tyr-4-nitroanilide + H2O | high activity | Mus musculus | methoxy-succinyl-Arg-Ala-Tyr + 4-nitroaniline | - |
? | |
| additional information | in position P1 a distinct preference for Phe and Ser is observed, in position P2 a high selectivity for Phe, Trp and Leu is detected, while P3 and P4 show specificity for aliphatic amino acids | Mus musculus | ? | - |
? | |
| protocadherin alpha-4 + H2O | potential substrate | Mus musculus | ? | - |
? | |
| Vitronectin + H2O | potential substrate | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-chymase | - |
Mus musculus |
| MCP-1 | - |
Mus musculus |
| mucosal mast cell protease | - |
Mus musculus |
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