Activating Compound | Comment | Organism | Structure |
---|---|---|---|
TGFbeta | treatment of human lung fibroblasts with TGF-beta1 results in a time-dependent increase in FXII production, activation of p44/42, p38, JNK, and Akt, and phosphorylation and translocation into the nucleus of Smad3 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
the FXII promoter contains the -299/+1 region, that is sufficient for TGF-beta1 to induce FXII expression | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | coagulation factor XII is a liver-derived serine protease involved in fibrinolysis, coagulation, and inflammation, regulation of FXII expression by TGF-beta-1, a multifunctional cytokine, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | coagulation factor XII is a liver-derived serine protease involved in fibrinolysis, coagulation, and inflammation, regulation of FXII expression by TGF-beta-1, a multifunctional cytokine, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
coagulation factor XII | - |
Homo sapiens |
FXII | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | transforming growth factor-beta1, TGF-beta1, a multifunctional cytokine, induces FXII expression, which is specifically repressed by the JNK inhibitor, and by JNK and Smad3 antisense oligonucleotides, but not by MEK, p38, or phosphoinositide 3-kinase blockers, overview. Treatment of human lung fibroblasts with TGF-beta1 results in a time-dependent increase in FXII production, activation of p44/42, p38, JNK, and Akt, and phosphorylation and translocation into the nucleus of Smad3. The FXII promoter contains the -299/+1 region, that is sufficient for TGF-beta1 to induce FXII expression, but the activation of FXII expression also requires Smad binding to TGF-beta1 at the a potential Smad binding element at position -272/-269 (SBE-(-272/-269)) of the TGF-beta1 promoter. JNK/Smad3 pathway plays a critical role in TGF-beta1-induced FXII expression in human lung fibroblasts | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the JNK/Smad3 pathway plays a critical role in TGF-beta1-induced FXII expression in human lung fibroblasts implicating its possible involvement in pathological conditions characterized by elevated TGF-beta1 levels | Homo sapiens |
physiological function | coagulation factor XII is a liver-derived serine protease involved in fibrinolysis, coagulation, and inflammation | Homo sapiens |