Literature summary for 3.4.21.26 extracted from

Larrinaga, G.; Perez, I.; Blanco, L.; Lopez, J.I.; Andres, L.; Etxezarraga, C.; Santaolalla, F.; Zabala, A.; Varona, A.; Irazusta, J.
Increased prolyl endopeptidase activity in human neoplasia (2010), Regul. Pept., 163, 102-106.

Search for more literature for 3.4.21.26

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	increase of cytosolic enzyme activity in clear cell renal cell carcinoma, urothelial carcinoma of the renal pelvis and head and neck squamous cell carcinoma, increase of cytosolic and membrane-bound enzyme activity in colorectal adenomatous polyps	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-
membrane	membrane-bound	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
chromophobe renal cell carcinoma cell	-	Homo sapiens	-
clear cell adenocarcinoma cell	kidney	Homo sapiens	-
colon	-	Homo sapiens	-
colonic adenocarcinoma cell	colon and rectum	Homo sapiens	-
colonic adenoma cell	colon and rectum	Homo sapiens	-
kidney	-	Homo sapiens	-
larynx	-	Homo sapiens	-
papillary thyroid cancer cell	thyroid	Homo sapiens	-
rectum	-	Homo sapiens	-
seminoma cell	testis	Homo sapiens	-
squamous cell carcinoma cell	oral cavity and larynx	Homo sapiens	-
testis	-	Homo sapiens	-
thyroid gland	-	Homo sapiens	-
urothelial carcinoma cell	of the renal pelvis	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.000000452	-	testicular seminoma, membrane-bound enzyme	Homo sapiens
0.000000465	-	healthy kidney, membrane-bound enzyme	Homo sapiens
0.000000507	-	clear cell renal cell carinoma, membrane-bound enzyme	Homo sapiens
0.000000567	-	healthy renal pelvis, membrane-bound enzyme	Homo sapiens
0.000000613	-	healthy thyroid, membrane-bound enzyme	Homo sapiens
0.000000634	-	healthy kidney, membrane-bound enzyme	Homo sapiens
0.000000696	-	healty testis, membrane-bound enzyme	Homo sapiens
0.000000737	-	healthy colorectum, membrane-bound enzyme	Homo sapiens
0.000000748	-	chromophobe renal cell carcinoma, membrane-bound enzyme	Homo sapiens
0.000000997	-	colorectal adenocarcinoma, membrane-bound enzyme	Homo sapiens
0.000001077	-	urothelial carcinoma of the renal pelvis, membrane-bound enzyme	Homo sapiens
0.000001182	-	healthy thyroid, cytosolic enzyme	Homo sapiens
0.000001236	-	head and neck squamous cell carcinoma, membrane-bound enzyme	Homo sapiens
0.000001323	-	squamous cell, membrane-bound enzyme	Homo sapiens
0.00000159	-	healty testis, cytosolic enzyme	Homo sapiens
0.000001694	-	papillary thyroid carcinoma, membrane-bound enzyme	Homo sapiens
0.000002733	-	healthy kidney, cytosolic enzyme	Homo sapiens
0.000002735	-	colorectal adenomatous poly, membrane-bound enzyme	Homo sapiens
0.000002849	-	testicular seminoma, cytosolic enzyme	Homo sapiens
0.000003163	-	healthy renal pelvis, cytosolic enzyme	Homo sapiens
0.000003179	-	chromophobe renal cell carcinoma, cytosolic enzyme	Homo sapiens
0.000003542	-	healthy kidney, cytosolic enzyme	Homo sapiens
0.000003679	-	clear cell renal cell carinoma, cytosolic enzyme	Homo sapiens
0.000004097	-	papillary thyroid carcinoma, cytosolic enzyme	Homo sapiens
0.000006846	-	squamous cell, cytosolic enzyme	Homo sapiens
0.000007659	-	urothelial carcinoma of the renal pelvis, cytosolic enzyme	Homo sapiens
0.000009287	-	healthy colorectum, cytosolic enzyme	Homo sapiens
0.00001134	-	head and neck squamous cell carcinoma, cytosolic enzyme	Homo sapiens
0.00001173	-	colorectal adenocarcinoma, cytosolic enzyme	Homo sapiens
0.00002357	-	colorectal adenomatous poly, cytosolic enzyme	Homo sapiens

Synonyms

Synonyms	Comment	Organism
prolyl endopeptidase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	involvement of enzyme in mechanisms of neoplastic processes suggested	Homo sapiens