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Literature summary for 3.4.21.26 extracted from

  • Larrinaga, G.; Perez, I.; Blanco, L.; Lopez, J.I.; Andres, L.; Etxezarraga, C.; Santaolalla, F.; Zabala, A.; Varona, A.; Irazusta, J.
    Increased prolyl endopeptidase activity in human neoplasia (2010), Regul. Pept., 163, 102-106.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information increase of cytosolic enzyme activity in clear cell renal cell carcinoma, urothelial carcinoma of the renal pelvis and head and neck squamous cell carcinoma, increase of cytosolic and membrane-bound enzyme activity in colorectal adenomatous polyps Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
membrane membrane-bound Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chromophobe renal cell carcinoma cell
-
Homo sapiens
-
clear cell adenocarcinoma cell kidney Homo sapiens
-
colon
-
Homo sapiens
-
colonic adenocarcinoma cell colon and rectum Homo sapiens
-
colonic adenoma cell colon and rectum Homo sapiens
-
kidney
-
Homo sapiens
-
larynx
-
Homo sapiens
-
papillary thyroid cancer cell thyroid Homo sapiens
-
rectum
-
Homo sapiens
-
seminoma cell testis Homo sapiens
-
squamous cell carcinoma cell oral cavity and larynx Homo sapiens
-
testis
-
Homo sapiens
-
thyroid gland
-
Homo sapiens
-
urothelial carcinoma cell of the renal pelvis Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [Āµmol/min/mg] Specific Activity Maximum [Āµmol/min/mg] Comment Organism
0.000000452
-
testicular seminoma, membrane-bound enzyme Homo sapiens
0.000000465
-
healthy kidney, membrane-bound enzyme Homo sapiens
0.000000507
-
clear cell renal cell carinoma, membrane-bound enzyme Homo sapiens
0.000000567
-
healthy renal pelvis, membrane-bound enzyme Homo sapiens
0.000000613
-
healthy thyroid, membrane-bound enzyme Homo sapiens
0.000000634
-
healthy kidney, membrane-bound enzyme Homo sapiens
0.000000696
-
healty testis, membrane-bound enzyme Homo sapiens
0.000000737
-
healthy colorectum, membrane-bound enzyme Homo sapiens
0.000000748
-
chromophobe renal cell carcinoma, membrane-bound enzyme Homo sapiens
0.000000997
-
colorectal adenocarcinoma, membrane-bound enzyme Homo sapiens
0.000001077
-
urothelial carcinoma of the renal pelvis, membrane-bound enzyme Homo sapiens
0.000001182
-
healthy thyroid, cytosolic enzyme Homo sapiens
0.000001236
-
head and neck squamous cell carcinoma, membrane-bound enzyme Homo sapiens
0.000001323
-
squamous cell, membrane-bound enzyme Homo sapiens
0.00000159
-
healty testis, cytosolic enzyme Homo sapiens
0.000001694
-
papillary thyroid carcinoma, membrane-bound enzyme Homo sapiens
0.000002733
-
healthy kidney, cytosolic enzyme Homo sapiens
0.000002735
-
colorectal adenomatous poly, membrane-bound enzyme Homo sapiens
0.000002849
-
testicular seminoma, cytosolic enzyme Homo sapiens
0.000003163
-
healthy renal pelvis, cytosolic enzyme Homo sapiens
0.000003179
-
chromophobe renal cell carcinoma, cytosolic enzyme Homo sapiens
0.000003542
-
healthy kidney, cytosolic enzyme Homo sapiens
0.000003679
-
clear cell renal cell carinoma, cytosolic enzyme Homo sapiens
0.000004097
-
papillary thyroid carcinoma, cytosolic enzyme Homo sapiens
0.000006846
-
squamous cell, cytosolic enzyme Homo sapiens
0.000007659
-
urothelial carcinoma of the renal pelvis, cytosolic enzyme Homo sapiens
0.000009287
-
healthy colorectum, cytosolic enzyme Homo sapiens
0.00001134
-
head and neck squamous cell carcinoma, cytosolic enzyme Homo sapiens
0.00001173
-
colorectal adenocarcinoma, cytosolic enzyme Homo sapiens
0.00002357
-
colorectal adenomatous poly, cytosolic enzyme Homo sapiens

Synonyms

Synonyms Comment Organism
prolyl endopeptidase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction involvement of enzyme in mechanisms of neoplastic processes suggested Homo sapiens