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Literature summary for extracted from

  • Wilkinson, F.H.; London, F.S.; Walsh, P.N.
    Residues 88-109 of factor IXa are important for assembly of the factor X activating complex (2002), J. Biol. Chem., 277, 5725-5733.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phospholipid membrane
Homo sapiens


Cloned (Comment) Organism
expression in HEK 293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
G94R 33% of wild-type vmax Homo sapiens
R94D slight increase in vmax Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
Factor X 37┬░C, pH 7.4, G94R mutant Homo sapiens
Factor X 37┬░C, pH 7.4 Homo sapiens
Factor X 37┬░C, pH 7.4, R94D mutant Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor X + H2O Homo sapiens
factor Xa


Organism UniProt Comment Textmining
Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
recombinant factor IXa Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor X + H2O
Homo sapiens factor Xa


Cofactor Comment Organism Structure
Factor VIIIa nonenzymatic cofactor Homo sapiens