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Literature summary for 3.4.21.22 extracted from

  • Wilkinson, F.H.; London, F.S.; Walsh, P.N.
    Residues 88-109 of factor IXa are important for assembly of the factor X activating complex (2002), J. Biol. Chem., 277, 5725-5733.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phospholipid membrane
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK 293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
G94R 33% of wild-type vmax Homo sapiens
R94D slight increase in vmax Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000016
-
Factor X 37┬░C, pH 7.4, G94R mutant Homo sapiens
0.000054
-
Factor X 37┬░C, pH 7.4 Homo sapiens
0.000071
-
Factor X 37┬░C, pH 7.4, R94D mutant Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor X + H2O Homo sapiens
-
factor Xa
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant factor IXa Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor X + H2O
-
Homo sapiens factor Xa
-
?

Cofactor

Cofactor Comment Organism Structure
Factor VIIIa nonenzymatic cofactor Homo sapiens