Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Factor VIIIa | the tenase complex, consisting of factor IXa and factor VIIIa assembled on a phospholipid-containing membrane, is the kinetically significant activator of factor X | Homo sapiens | |
phospholipid membrane | phospholipid vesicles composed of 1-palmityl-2-oleoyl-sn-glycero-3-phosphoethanolamine, phosphatidylserine and phosphatidylcholine support factor Xa generation | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000037 | - |
Factor X | 25°C, pH 7.4, in the presence of phospholipid vesicle containing 79% phosphatidylcholine, 1% phosphatidylserine and 20% phosphatidylethanolamine | Homo sapiens | |
0.38 | - |
Factor X | 25°C, pH 7.4, in the presence of phospholipid vesicle containing 79% phosphatidylcholine, 1% phosphatidylserine and 20% phosphatidylethanolamine | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | Homo sapiens | - |
factor Xa | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | - |
Homo sapiens | factor Xa | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | the catalytic efficiency kcat/Km, of phospholipid vesicles containing 20 or 35% phosphatidylethanolamine and no phosphatidylserine is 5.5fold higher than that of vesicles containing 1% phosphatidylserine and no phosphatidylethanolamine | Homo sapiens | |
additional information | - |
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(1-benzyl-2-oxo-2-thiazol-2-yl-ethyl)-acetamide | the catalytic efficiency kcat/Km, of phospholipid vesicles containing 20 or 35% phosphatidylethanolamine and no phosphatidylserine is 5.5fold higher than that of vesicles containing 1% phosphatidylserine and no phosphatidylethanolamine | Homo sapiens | |
0.38 | - |
Factor X | 25°C, pH 7.4, in the presence of phospholipid vesicle containing 79% phosphatidylcholine, 1% phosphatidylserine and 20% phosphatidylethanolamine | Homo sapiens |