Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Factor VIIIa | 200000fold activation in the presence of phospholipid membrane through a combinantion of a decrease in Km and an increase in kcat | Homo sapiens | |
GIGAVLKVLTTGLPALISSWIKRKRQQ | approx. 600fold lower km, slight increase in kcat | Homo sapiens | |
phospholipid membrane | 200000fold activation in the presence of factor VIIIa through a combinantion of a decrease in Km and an increase in kcat | Homo sapiens | |
TRYLRIHPQSWVHQIALRMEV | approx. 600fold lower km, slight increase in kcat, optimal activation in the presence of 0.5-1 mM Ca2+ | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00013 | - |
Factor X | 25°C, pH 7.4, in the presence of GIGAVLKVLTTGLPALISSWIKRKRQQ | Homo sapiens | |
0.00017 | - |
Factor X | 25°C, pH 7.4, in the presence of TRYLRIHPQSWVHQIALRMEV | Homo sapiens | |
0.095 | - |
Factor X | 25°C, pH 7.4 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 5 mM, optimal concentration for cleavage of factor X by factor IXa on phospholipid membranes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | Homo sapiens | - |
fragments of factor X | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | - |
Homo sapiens | fragments of factor X | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00016 | - |
Factor X | 25°C, pH 7.4 | Homo sapiens | |
0.00023 | - |
Factor X | 25°C, pH 7.4, in the presence of GIGAVLKVLTTGLPALISSWIKRKRQQ | Homo sapiens | |
0.00025 | - |
Factor X | 25°C, pH 7.4, in the presence of TRYLRIHPQSWVHQIALRMEV | Homo sapiens |