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Literature summary for 3.4.21.21 extracted from
- Factor VIIa-induced interaction with integrin controls the release of tissue factor on extracellular vesicles from endothelial cells (2019), J. Thromb. Haemost., 17, 627-634 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Factor X + H2O | Homo sapiens | - |
Factor Xa + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Factor X + H2O | - |
Homo sapiens | Factor Xa + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FVIIa | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | factor VIIa-induced interaction with integrin controls the release of tissue factor on extracellular vesicles from endothelial cells. Intracellular trafficking controlled by factor FVIIa forcing interaction with integrin beta1 regulates tissue factor availability for release on procoagulant extracellular vesicles | Homo sapiens |
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