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Literature summary for 3.4.21.20 extracted from
- Luminal cathepsin g and protease-activated receptor 4: a duet involved in alterations of the colonic epithelial barrier in ulcerative colitis (2009), Am. J. Pathol., 175, 207-214.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride | - |
Homo sapiens |  |
| specific Cat-G inhibitor | 1 microM, decrease of enzyme activity by 43% | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 39000 | - |
Western blot | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colon | - |
Homo sapiens | - |
| feces | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
7% cathepsin G acitivity among total proteolytic activity of fecal supernatants, in healthy patients | Homo sapiens |
| additional information | - |
15% cathepsin G acitivity among total proteolytic activity of fecal supernatants, in patients with ulcerative colitits | Homo sapiens |
| 2.02 | - |
healthy subjects | Homo sapiens |
| 16.14 | - |
patients with ulcerative colitis and specific Cat-G inhibitor | Homo sapiens |
| 28.34 | - |
patients with ulcerative colitis | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O | assay at 37°C | Homo sapiens | N-succinyl-Ala-Ala-Pro-Phe + p-nitroaniline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cat-G | - |
Homo sapiens |
| cathepsin G | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | higher expression of Cat-G in biopsies from patients with ulcerative colitis | up |
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