Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a therapeutic target | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
the gene is located at chromosome 14q11.2 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha1-Aantichymotrypsin | - |
Homo sapiens | |
alpha1-protease inhibitor | - |
Homo sapiens | |
alpha2-Macroglobulin | - |
Homo sapiens | |
chelonianin | - |
Homo sapiens | |
monocyte neutrophil elastase inhibitor | - |
Homo sapiens | |
additional information | inhibition mechanisms, overview | Homo sapiens | |
protease inhibitor PI6 | - |
Homo sapiens | |
secretory leukocyteprotease inhibitor | - |
Homo sapiens | |
serpin | - |
Homo sapiens | |
squamous cell carcinoma antigen 2 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | active enzyme | Homo sapiens | 9986 | - |
extracellular | active enzyme | Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
28500 | - |
x * 28500 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is one of the major components of the neutrophil primary granules that participate in the non-oxidative pathway of intracellular pathogen destruction, it helps kill bacterial cells and is involved in the degradation of extracellular matrix components during acute and chronic inflammation, the enzyme is important in regulation of immune response, control of cellular signaling through the procession of cytokines and modulation of the cytokine network, biological functions and roles in diseases of cathepsin G, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08311 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | the enzyme contains one glycosylation site | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
monocyte | enzyme synthesis | Homo sapiens | - |
neutrophil | polymorphonuclear cells, enzyme synthesis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Abz-EPFWEDQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | the enzyme is one of the major components of the neutrophil primary granules that participate in the non-oxidative pathway of intracellular pathogen destruction, it helps kill bacterial cells and is involved in the degradation of extracellular matrix components during acute and chronic inflammation, the enzyme is important in regulation of immune response, control of cellular signaling through the procession of cytokines and modulation of the cytokine network, biological functions and roles in diseases of cathepsin G, overview | Homo sapiens | ? | - |
? | |
additional information | cathepsin G prefers aromatic or positively charged residues at P1 position, e.g. Phe, Tyr, Lys, or Arg, substrate specificity and active site structure analysis, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 28500 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the chymotrypsin family | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Homo sapiens |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Homo sapiens | about | - |
12 |