Application | Comment | Organism |
---|---|---|
medicine | JNJ-10311795 is an inhibitor of cathepsin G and chymase. The possibility to inhibit both cathepsin G and chymase with a single molecule suggests an exciting opportunity in the treatment of asthma and chronic obstructive pulmonary disease | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
enzyme complexed with the inhibitor JNJ-10311795, 1.85 A resolution | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
JNJ-10311795 | inhibitor of cathepsin G and chymase. The possibility to inhibit both cathepsin G and chymase with a single molecule suggests an opportunity in the treatment of asthma and chronic obstructive pulmonary disease | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08311 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | - |
Homo sapiens | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000038 | - |
JNJ-10311795 | - |
Homo sapiens |