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Literature summary for 3.4.21.114 extracted from
- Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and Is essential for virus replication (1999), J. Virol., 73, 2027-2037.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
equine arteritis virus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S1184I | no cleavage between nsp9 and nsp10 | equine arteritis virus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | equine arteritis virus | enzyme is the main viral protease | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| equine arteritis virus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arterivirus replicase ORF1b + H2O | protein is processed by nsp4 serine protease at the following sites: nsp9/10 i.e. p80/p50, cleavage occurs between Glu2370 and Ser, nsp10/11 i.e. p50/p26, cleavage occurs between Gln2837 and Ser, nsp11/12 i.e. nsp26/p12, cleavage between Glu3056 and Gly | equine arteritis virus | ? | - |
? | |
| additional information | enzyme is the main viral protease | equine arteritis virus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| nsp4 | - |
equine arteritis virus |
| nsp4 serine protease | - |
equine arteritis virus |
| nsp4SP | - |
equine arteritis virus |
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