Literature summary for 3.4.21.110 extracted from

Li, H.; Wang, S.; Zhao, Y.; Chen, Z.; Gu, G.; Guo, Z.
Mutagenesis and immunological evaluation of group A streptococcal C5a peptidase as an antigen for vaccine development and as a carrier protein for glycoconjugate vaccine design (2017), RSC Adv., 7, 42056-42063 .

No PubMed abstract available

Search for more literature for 3.4.21.110

Application

Application	Comment	Organism
medicine	inactive mutant H193A elicits high titers of antigen-specific IgG1 antibodies and robust T cell-mediated immunities in mice showing potential as a Streptococcus vaccine. Cconjugating the trisaccharide repeating unit of Streptococcus polysaccharide with mutant H193A converts the nonimmunogenic oligosaccharide into a highly active and T cell-dependent antigen	Streptococcus pyogenes

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Streptococcus pyogenes

Protein Variants

Protein Variants	Comment	Organism
D130A	residue is not critical for catalytic activity	Streptococcus pyogenes
H193A	complete loss of activity	Streptococcus pyogenes
N295A	residue is not critical for catalytic activity	Streptococcus pyogenes
S512A	residue is not critical for catalytic activity	Streptococcus pyogenes

Organism

Organism	UniProt	Comment	Textmining
Streptococcus pyogenes	B6ETQ5	-	-

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Release 2023.1 (January 2023)