Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1r,4r)-4-amino-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)cyclohexanecarboxamide | - |
Homo sapiens | |
(1r,4r)-4-aminocyclohexyl 3,5-bis(4-carbamimidoylphenoxy)benzoate | - |
Homo sapiens | |
1-(2-aminoethyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide | - |
Homo sapiens | |
1-(3,5-bis(4-carbamimidoylphenoxy)benzoyl)piperidine-4-carboxylic acid | - |
Homo sapiens | |
1-(3-aminopropanoyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide | - |
Homo sapiens | |
3,5-bis(4-carbamimidoylphenoxy)-N-((4-hydroxycyclohexyl)methyl)benzamide | - |
Homo sapiens | |
3,5-bis(4-carbamimidoylphenoxy)-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide | - |
Homo sapiens | |
3,5-bis(4-carbamimidoylphenoxy)-N-(4-fluorophenyl)benzamide | - |
Homo sapiens | |
3,5-bis(4-carbamimidoylphenoxy)-N-(4-hydroxycyclohexyl)benzamide | - |
Homo sapiens | |
3,5-bis(4-carbamimidoylphenoxy)-N-(4-methylcyclohexyl)benzamide | - |
Homo sapiens | |
3,5-bis(4-carbamimidoylphenoxy)-N-(cyclohexylmethyl)benzamide | - |
Homo sapiens | |
3,5-bis(4-carbamimidoylphenoxy)-N-cyclohexylbenzamide | - |
Homo sapiens | |
3,5-bis(4-carbamimidoylphenoxy)benzamide | - |
Homo sapiens | |
3-[(2R)-3-[4-(2-aminoethyl)piperidin-1-yl]-2-([[3-(6-amino-2,3,4,5-tetrahydropyridin-3-yl)phenyl]sulfonyl]amino)-3-oxopropyl]benzenecarboximidamide | - |
Homo sapiens | |
3-[3-[4-(2-carbamimidamidoethyl)piperidin-1-yl]-2-[(naphthalen-2-ylsulfonyl)amino]-3-oxopropyl]benzenecarboximidamide | - |
Homo sapiens | |
4,4'-((5-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide | - |
Homo sapiens | |
4,4'-((5-(4-(2-aminoethyl)piperidine-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide | - |
Homo sapiens | |
4,4'-((5-(4-fluorophenylsulfonamido)-1,3-phenylene)bis(oxy))dibenzimidamide | - |
Homo sapiens | |
4,4'-((5-(decahydroquinoline-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide | - |
Homo sapiens | |
4,4'-((5-(naphthalene-2-sulfonamido)-1,3-phenylene)bis(oxy))dibenzimidamide | - |
Homo sapiens | |
4,4'-[(3-[[(4-fluorophenyl)sulfonyl]amino]pyridine-2,6-diyl)bis(oxy)]dibenzenecarboximidamide | - |
Homo sapiens | |
4,4'-[(5-aminobenzene-1,3-diyl)bis(oxy)]dibenzenecarboximidamide | - |
Homo sapiens | |
4,4'-[benzene-1,4-diylbis(oxy)]dibenzenecarboximidamide | binding structure, overview | Homo sapiens | |
4-aminocyclohexyl 3,5-bis(4-carbamimidoylphenoxy)benzoate | - |
Homo sapiens | |
4-[(2-[[(2S)-6-carbamimidamido-1-oxohexan-2-yl]amino]-2-oxoethyl)carbamoyl]-6-methoxy-6-oxo-4-[3-(prop-1-en-2-yl)benzyl]hexanoic acid | - |
Homo sapiens | |
ethyl 4-(3,5-bis(4-carbamimidoylphenoxy)benzamido)piperidine-1-carboxylate | - |
Homo sapiens | |
additional information | inhibitor design, synthesis of diverse 5-substituted phenylene1,3-bis(oxy) dibenzimidamide analogues, overview. Anaysis of cytotoxic effects of inhibitors | Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3,5-bis((3-carbamimidoylbenzyl)oxy)benzamide | - |
Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3,5-bis((4-carbamimidoylbenzyl)oxy)benzamide | - |
Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3,5-bis(4-(aminomethyl)phenoxy)benzamide | - |
Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3-((3-carbamimidoylbenzyl)oxy)-5-(4-carbamimidoylphenoxy)benzamide | - |
Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3-((4-bromobenzyl)oxy)-5-(4-carbamimidoylphenoxy)benzamide | - |
Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3-((4-carbamimidoylbenzyl)oxy)-5-(4-carbamimidoylphenoxy)benzamide | - |
Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3-((6-aminopyridin-3-yl)oxy)-5-(4-carbamimidoylphenoxy)benzamide | - |
Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3-((6-bromopyridin-3-yl)methoxy)-5-(4-carbamimidoylphenoxy)benzamide | - |
Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3-(4-(3-aminopropanamido)phenoxy)-5-(4-carbamimidoylphenoxy)benzamide | - |
Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3-(4-(aminomethyl)phenoxy)-5-(4-carbamimidoylphenoxy)benzamide | - |
Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3-(4-aminophenoxy)-5-(4-carbamimidoylphenoxy)benzamide | - |
Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3-(4-carbamimidoylphenoxy)-5-((4-chlorobenzyl)oxy)benzamide | - |
Homo sapiens | |
N-((1r,4r)-4-aminocyclohexyl)-3-(4-carbamimidoylphenoxy)-5-(4-carbamoylphenoxy)benzamide | - |
Homo sapiens | |
N-(1-(3-aminopropyl)piperidin-4-yl)-3,5-bis(4-carbamimidoylphenoxy)benzamide | - |
Homo sapiens | |
N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)-1-(2-hydroxyethyl)piperidine-4-carboxamide | - |
Homo sapiens | |
N-(4-aminocyclohexyl)-3,5-bis(4-carbamimidoylphenoxy)benzamide | - |
Homo sapiens | |
N-[3-([1-[4-(2-aminoethyl)piperidin-1-yl]-3-(3-carbamimidoylphenyl)-1-oxopropan-2-yl]sulfamoyl)phenyl]-b-alaninamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y5Y6 | - |
- |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000001 | - |
(1r,4r)-4-aminocyclohexyl 3,5-bis(4-carbamimidoylphenoxy)benzoate | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000003 | - |
(1r,4r)-4-amino-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)cyclohexanecarboxamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000003 | - |
N-((1r,4r)-4-aminocyclohexyl)-3,5-bis((3-carbamimidoylbenzyl)oxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000006 | - |
N-((1r,4r)-4-aminocyclohexyl)-3-((3-carbamimidoylbenzyl)oxy)-5-(4-carbamimidoylphenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00001 | - |
N-(4-aminocyclohexyl)-3,5-bis(4-carbamimidoylphenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00001 | - |
N-((1r,4r)-4-aminocyclohexyl)-3-((4-carbamimidoylbenzyl)oxy)-5-(4-carbamimidoylphenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000018 | - |
1-(2-aminoethyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000018 | - |
N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)-1-(2-hydroxyethyl)piperidine-4-carboxamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000023 | - |
N-((1r,4r)-4-aminocyclohexyl)-3,5-bis((4-carbamimidoylbenzyl)oxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00004 | - |
N-((1r,4r)-4-aminocyclohexyl)-3-(4-(aminomethyl)phenoxy)-5-(4-carbamimidoylphenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000061 | - |
1-(3-aminopropanoyl)-N-(3,5-bis(4-carbamimidoylphenoxy)phenyl)piperidine-4-carboxamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000094 | - |
4,4'-((5-(4-(2-aminoethyl)piperidine-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000116 | - |
N-((1r,4r)-4-aminocyclohexyl)-3-(4-(3-aminopropanamido)phenoxy)-5-(4-carbamimidoylphenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000141 | - |
N-(1-(3-aminopropyl)piperidin-4-yl)-3,5-bis(4-carbamimidoylphenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000204 | - |
3,5-bis(4-carbamimidoylphenoxy)-N-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000218 | - |
4,4'-[(3-[[(4-fluorophenyl)sulfonyl]amino]pyridine-2,6-diyl)bis(oxy)]dibenzenecarboximidamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00026 | - |
N-((1r,4r)-4-aminocyclohexyl)-3-((4-bromobenzyl)oxy)-5-(4-carbamimidoylphenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000301 | - |
3,5-bis(4-carbamimidoylphenoxy)-N-(4-hydroxycyclohexyl)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000305 | - |
4,4'-((5-(decahydroquinoline-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000411 | - |
3,5-bis(4-carbamimidoylphenoxy)-N-(cyclohexylmethyl)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00047 | - |
N-((1r,4r)-4-aminocyclohexyl)-3-(4-carbamimidoylphenoxy)-5-((4-chlorobenzyl)oxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000545 | - |
4-aminocyclohexyl 3,5-bis(4-carbamimidoylphenoxy)benzoate | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000591 | - |
3,5-bis(4-carbamimidoylphenoxy)-N-(4-fluorophenyl)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000592 | - |
3,5-bis(4-carbamimidoylphenoxy)-N-cyclohexylbenzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00073 | - |
4,4'-((5-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00077 | - |
3,5-bis(4-carbamimidoylphenoxy)-N-(4-methylcyclohexyl)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000793 | - |
N-((1r,4r)-4-aminocyclohexyl)-3-((6-bromopyridin-3-yl)methoxy)-5-(4-carbamimidoylphenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.000824 | - |
N-((1r,4r)-4-aminocyclohexyl)-3-(4-carbamimidoylphenoxy)-5-(4-carbamoylphenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00106 | - |
4,4'-[(5-aminobenzene-1,3-diyl)bis(oxy)]dibenzenecarboximidamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00113 | - |
N-((1r,4r)-4-aminocyclohexyl)-3-(4-aminophenoxy)-5-(4-carbamimidoylphenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.001182 | - |
3,5-bis(4-carbamimidoylphenoxy)-N-((4-hydroxycyclohexyl)methyl)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00162 | - |
3,5-bis(4-carbamimidoylphenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.001698 | - |
N-((1r,4r)-4-aminocyclohexyl)-3,5-bis(4-(aminomethyl)phenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00179 | - |
4,4'-((5-(naphthalene-2-sulfonamido)-1,3-phenylene)bis(oxy))dibenzimidamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00185 | - |
ethyl 4-(3,5-bis(4-carbamimidoylphenoxy)benzamido)piperidine-1-carboxylate | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00198 | - |
4,4'-((5-(4-fluorophenylsulfonamido)-1,3-phenylene)bis(oxy))dibenzimidamide | pH 8.5, temperature not specified in the publication | Homo sapiens | |
0.00203 | - |
N-((1r,4r)-4-aminocyclohexyl)-3-((6-aminopyridin-3-yl)oxy)-5-(4-carbamimidoylphenoxy)benzamide | pH 8.5, temperature not specified in the publication | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | expression of matriptase is frequently dysregulated in human cancers | Homo sapiens |
physiological function | matriptase is a serine protease implicated in cancer invasion and metastasis, matriptase activates latent growth factors such as hepatocyte growth factor/scatter factor, and proteases such as urokinase plasminogen activator | Homo sapiens |