Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SFTI1 | serine protease inhibitor can only inhibit Epi/MTP and cathepsin G. Mammary epithelial growth and morphogenesis in the presence of the latent form hepatocyte growth factor (pro-HGF) is blocked by addition of SFTI1 an inhibitor of the Epi/MTP protease activity | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mammary epithelium | Epi/MTP is expressed at low level in the mouse mammary epithelium of young animals and it accumulates at the terminal end-bud of the growing ducts. The level of Epi/MTP is elevated in the mammary glands at stages when epithelial proliferation and modeling occur. It is primarily present in the luminal epithelial cells of mouse mammary ducts and lobules | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Epi/MTP | - |
Mus musculus |
epithin/matriptase | - |
Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000092 | - |
SFTI1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | Epi/MTP is expressed at low level in the mouse mammary epithelium of young animals | down |
Mus musculus | level of Epi/MTP is elevated in the mammary glands at stages when epithelial proliferation and modeling occur | up |
General Information | Comment | Organism |
---|---|---|
malfunction | mammary epithelial growth and morphogenesis in the presence of the latent form hepatocyte growth factor (pro-HGF) is blocked either by addition of SFTI1 an inhibitor of the Epi/MTP protease activity or by siRNA knockdown of the Epi/MTP expression | Mus musculus |
physiological function | Epi/MTP participates in mammary epithelial growth and modeling through activation of pro-hepatocyte growth factor | Mus musculus |