Protein Variants | Comment | Organism |
---|---|---|
S306A | catalytically inactive mutant | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BA/F3 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
receptor-interacting protein 1 + H2O | the HtrA2/Omi cleavage site receptor-interacting protein 1 is mapped to the intermediate domain and the corresponding N- and C-terminal fragments are impaired in their ability to activate nuclear factor-kappaB, c-Jun N-terminal kinase and p38 mitogen-activated protein kinase | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
high temperature requirement protein A2 | - |
Mus musculus |
HtrA2/Omi | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of HtrA2/Omi affords protection against interleukin-3 withdrawal-induced death in the presence of carbobenzoxy-valyl-analylaspartyl-[O-methyl]-fluoromethylketone | Mus musculus |
physiological function | HtrA2/Omi plays a role in caspase-independent cell death during growth factor withdrawal by cleaving receptor-interacting protein 1 | Mus musculus |