Cloned (Comment) | Organism |
---|---|
- |
Mammalia |
Protein Variants | Comment | Organism |
---|---|---|
A144G | mutation reduces ability to promote cell death, weak interaction with XIAP | Mammalia |
A147I | increased affinity for the BIR3 domain of XIAP | Mammalia |
S306A | mutation reduces ability to promote cell death | Mammalia |
S306A/A144G | complete loss of proapoptotic activity | Mammalia |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mammalia | 16020 | - |
mitochondrion | in response to UV irradiation the enzyme shifts into the cytosol | Mammalia | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
calculated from nucleotide sequence | Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mammalia | role in apoptosis, mice with mutant HtrA2/Omi suffer from neurodegenerative disease due to progressive mitochondrial damage, mutant enzyme is proteolytically inactive but can bind to IAPs | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | precursor protein is processed to yield an active protase | Mammalia |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-casein + H2O | - |
Mammalia | ? | - |
? | |
additional information | role in apoptosis, mice with mutant HtrA2/Omi suffer from neurodegenerative disease due to progressive mitochondrial damage, mutant enzyme is proteolytically inactive but can bind to IAPs | Mammalia | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HtrA2/Omi | - |
Mammalia |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mammalia |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Mammalia |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Mammalia | calculated from nucleotide sequence | - |
6.7 |