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Literature summary for 3.4.21.107 extracted from

  • Campioni, M.; Severino, A.; Manente, L.; Tuduce, I.L.; Toldo, S.; Caraglia, M.; Crispi, S.; Ehrmann, M.; He, X.; Maguire, J.; De Falco, M.; De Luca, A.; Shridhar, V.; Baldi, A.
    The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein (2010), Mol. Cancer Res., 8, 1248-1260.
    View publication on PubMed
Search for more literature for 3.4.21.107

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
S328A enzymatically inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
extracellular
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
 x * 70000, about 70000 kDa, GST-tagged enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tuberous sclerosis complex 2 protein + H2O Homo sapiens specific substrate for HtrA1 which is cleaved both in vitro and in vivo ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose bead chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-2780 cell
-
 Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-
TOV-21G cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
additional information HtrA1 shows no activity towards tuberous sclerosis complex 1 protein and bovine serum albumin Homo sapiens ?
-
 ?
tuberous sclerosis complex 2 protein + H2O specific substrate for HtrA1 which is cleaved both in vitro and in vivo Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 70000, about 70000 kDa, GST-tagged enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
high-temperature requirement A1 protease
-
 Homo sapiens
HtrA1
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism one of the targets of HtrA1 activity during fetal development is the tuberous sclerosis complex 2-tuberous sclerosis complex 1 pathway Homo sapiens