Inhibitors | Comment | Organism | Structure |
---|---|---|---|
HpHtrA inhibitor | small-molecule inhibitor that completely blocks E-cadherin cleavage by HtrA at 0.03 mM | Helicobacter pylori |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, SDS-PAGE | Helicobacter pylori |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
E-cadherin + H2O | Helicobacter pylori | selective substrate | 85 kDa N-terminal fragment + 40 kDa C-terminal fragment | - |
? | |
Fibronectin + H2O | Helicobacter pylori | selective substrate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicobacter pylori | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Helicobacter pylori |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
casein + H2O | - |
Helicobacter pylori | ? | - |
? | |
E-cadherin + H2O | selective substrate | Helicobacter pylori | 85 kDa N-terminal fragment + 40 kDa C-terminal fragment | - |
? | |
Fibronectin + H2O | selective substrate | Helicobacter pylori | ? | - |
? | |
additional information | the enzyme does not cleave recombinant immunoglobulin A, epidermal growth factor receptor or junctional adhesion molecule | Helicobacter pylori | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, SDS-PAGE | Helicobacter pylori |
Synonyms | Comment | Organism |
---|---|---|
high-temperature requirement A protease | - |
Helicobacter pylori |
HtrA | - |
Helicobacter pylori |
General Information | Comment | Organism |
---|---|---|
physiological function | HtrA is a secreted virulence factor from Helicobacter pylori, which cleaves the ectodomain of E-cadherin. the E-cadherin shedding disrupts epithelial barrier functions allowing Helicobacter pylori to access the intercellular space | Helicobacter pylori |