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Literature summary for 3.4.21.107 extracted from

  • Yuan, L.; Rodrigues, P.H.; Belanger, M.; Dunn, W.A.; Progulske-Fox, A.
    Porphyromonas gingivalis htrA is involved in cellular invasion and in vivo survival (2008), Microbiology, 154, 1161-1169.
    View publication on PubMed
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Application

Application Comment Organism
molecular biology htrA gene in Porphyromonas gingivalis does not relate to stress conditions such as high temperature and pH, but rather to H2O2 stress. The htrA gene is important for virulence and survival in in vivo animal models Porphyromonas gingivalis

Protein Variants

Protein Variants Comment Organism
additional information a htrA mutant, consisting of a truncated gene, demonstrates no significant difference to the W83 parent strain when subjected to high temperature and pH values from 3 to 11. Mutant shows increased sensitivity to H2O2. HtrA mutant shows increased invasion in KB cells and gingival epithelial cells. Microarray experiments indicate that a total of 253 genes are differentially regulated in the htrA mutant, including a group of stress-related genes. In animal experiments, a competition assay shows that the htrA mutant does not survive as well as the wild-type. Fewer mice infected with the htrA mutant die than mice infected with W83, suggesting that the htrA gene is virulence-related Porphyromonas gingivalis

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
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Synonyms

Synonyms Comment Organism
HtrA
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 Porphyromonas gingivalis