Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05981 | - |
- |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | hepsin expression correlates with synovitis as well as tumour necrosis factor alpha expression, and is induced in cartilage by a pro-inflammatory stimulus | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | addition of hepsin to osteoarthritis cartilage in explant culture induces significant collagen and aggrecan release and activates metalloproteinases proMMP-1 and proMMP-3. Hepsin directly cleaves the aggrecan core protein at a cleavage site within the interglobular domain. Hepsin expression correlates with synovitis as well as tumour necrosis factor alpha expression, and is induced in cartilage by a pro-inflammatory stimulus. Hepsin demonstrates markedly reduced capacity to activate proteinase-activated receptor-2, compared with matriptase | Homo sapiens |