Literature summary for 3.4.21.106 extracted from

Subedi, M.; Minn, I.; Chen, J.; Kim, Y.; Ok, K.; Jung, Y.W.; Pomper, M.G.; Byun, Y.
Design, synthesis and biological evaluation of PSMA/hepsin-targeted heterobivalent ligands (2016), Eur. J. Med. Chem., 118, 208-218 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	synthesis of a heterobivalent inhibitor, targeting both hepsin and prostate-specific membrane antigen, EC 3.4.17.21. The compound is based on an amidine-containing indole analog linked with Lys-urea-Glu for binding to prostate-specific membrane antigen, and the optical dye SulfoCy7. Compound shows selective binding and retention in both prostate-specific membrane antigen and hepsin high-expressing cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05981	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
t-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumaryl-7-amide + H2O	-	Homo sapiens	t-butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin	-	?

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Release 2023.1 (January 2023)