BRENDA - Enzyme Database show
show all sequences of 3.4.21.104

The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions

Harmat, V.; Gal, P.; Kardos, J.; Szilagyi, K.; Ambrus, G.; Vegh, B.; Naray-Szabo, G.; Zavodszky, P.; J. Mol. Biol. 342, 1533-1546 (2004)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression of the catalytic fragment encompassing the second complement control protein module and the serine protease domain, i.e. MASP-2-CCP2-SP, in Escherichia coli strain BL21(DE3), the recombinant construct contains an extra-tetrapeptide ASMT at the N-terminus
Homo sapiens
Crystallization (Commentary)
Crystallization
Organism
catalytic fragment encompassing the second complement control protein module and the serine protease domain, in presence of Na+, in absence of Mg2+, 0.8 mg/ml purified recombinant protein in 140 mM NaCl, 20 mM Tris-HCl, pH 7.4, and 0.05% w/v NaN3, hanging drop vapour diffusion method at 20°C, mixing with equal volume of reservoir solution containing 30% w/v PEG 6000, 0.2 M NaCl, 10% v/v glycerol, 0.1 M Tris-HCl, pH 7.5, X-ray diffraction structure determination and analysis at 2.25 A resolution
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
no inhibition by Na+
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetics
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
additional information
no induction by Na+
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
complement component C2 + H2O
Homo sapiens
-
2 fragments of complement component C2
-
-
?
complement component C4 + H2O
Homo sapiens
-
2 fragments of complement C4
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q92876
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
no glycoprotein
-
Homo sapiens
proteolytic modification
autoactivation
Homo sapiens
Purification (Commentary)
Commentary
Organism
recombinant catalytic fragment encompassing the second complement control protein module and the serine protease domain, i.e. MASP-2-CCP2-SP, from Escherichia coli strain BL21(DE3)
Homo sapiens
Reaction
Reaction
Commentary
Organism
Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile)
structure-function analysis of the catalytic unit, enzyme-substrate interaction is different from enzyme C1 which has the same substrate specificity, MASP-2 shows a subsite flexibility in substrate specificity, catalytic residues are Asp526 and His525, active site structure, overview
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4,4'-dithiopyridine + H2O
-
659718
Homo sapiens
?
-
-
-
?
alpha-N-benzyloxycarbonyl-L-lysine thiobenzyl ester + H2O
-
659718
Homo sapiens
?
-
-
-
?
complement component C2 + H2O
-
659718
Homo sapiens
2 fragments of complement component C2
-
-
-
?
complement component C4 + H2O
-
659718
Homo sapiens
2 fragments of complement C4
-
-
-
?
complement component C4 + H2O
the complement control protein CCP module is essential for cleavage
659718
Homo sapiens
2 fragments of complement C4
-
-
-
?
Subunits
Subunits
Commentary
Organism
More
enzyme surface segment analysis, structure-function analysis
Homo sapiens
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
assay at
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of the catalytic fragment encompassing the second complement control protein module and the serine protease domain, i.e. MASP-2-CCP2-SP, in Escherichia coli strain BL21(DE3), the recombinant construct contains an extra-tetrapeptide ASMT at the N-terminus
Homo sapiens
Crystallization (Commentary) (protein specific)
Crystallization
Organism
catalytic fragment encompassing the second complement control protein module and the serine protease domain, in presence of Na+, in absence of Mg2+, 0.8 mg/ml purified recombinant protein in 140 mM NaCl, 20 mM Tris-HCl, pH 7.4, and 0.05% w/v NaN3, hanging drop vapour diffusion method at 20°C, mixing with equal volume of reservoir solution containing 30% w/v PEG 6000, 0.2 M NaCl, 10% v/v glycerol, 0.1 M Tris-HCl, pH 7.5, X-ray diffraction structure determination and analysis at 2.25 A resolution
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
no inhibition by Na+
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetics
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
additional information
no induction by Na+
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
complement component C2 + H2O
Homo sapiens
-
2 fragments of complement component C2
-
-
?
complement component C4 + H2O
Homo sapiens
-
2 fragments of complement C4
-
-
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
no glycoprotein
-
Homo sapiens
proteolytic modification
autoactivation
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant catalytic fragment encompassing the second complement control protein module and the serine protease domain, i.e. MASP-2-CCP2-SP, from Escherichia coli strain BL21(DE3)
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4,4'-dithiopyridine + H2O
-
659718
Homo sapiens
?
-
-
-
?
alpha-N-benzyloxycarbonyl-L-lysine thiobenzyl ester + H2O
-
659718
Homo sapiens
?
-
-
-
?
complement component C2 + H2O
-
659718
Homo sapiens
2 fragments of complement component C2
-
-
-
?
complement component C4 + H2O
-
659718
Homo sapiens
2 fragments of complement C4
-
-
-
?
complement component C4 + H2O
the complement control protein CCP module is essential for cleavage
659718
Homo sapiens
2 fragments of complement C4
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
More
enzyme surface segment analysis, structure-function analysis
Homo sapiens
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
assay at
Homo sapiens
Other publictions for EC 3.4.21.104
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
731745
Keizer
TFPI inhibits lectin pathway o ...
Homo sapiens
Eur. J. Immunol.
45
544-550
2015
-
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731780
Asgari
Mannan-binding lectin-associat ...
Mus musculus
FASEB J.
28
3996-4003
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
732518
Parej
Dissociation and re-associatio ...
Homo sapiens
Mol. Immunol.
59
1-9
2014
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
732265
Degn
Co-complexes of MASP-1 and MAS ...
Homo sapiens
J. Immunol.
191
1334-1345
2013
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
718122
Duncan
Multiple domains of MASP-2, an ...
Homo sapiens
Mol. Immunol.
49
593-600
2012
-
-
1
-
1
-
1
1
-
-
1
-
-
1
-
-
1
-
-
1
-
-
4
1
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
1
-
-
1
-
-
-
-
1
-
1
-
-
4
1
-
-
-
2
-
-
-
-
-
1
1
-
-
-
732057
Heja
Monospecific inhibitors show t ...
Homo sapiens
J. Biol. Chem.
287
20290-20300
2012
-
-
-
1
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718181
Novovic
Mannan-binding lectin and mann ...
Homo sapiens
Pancreas
40
1097-1102
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
708201
Miller
Molecular defects in the manno ...
Homo sapiens
Clin. Mol. Allergy
8
6-6
2010
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
708697
Gulla
Activation of mannan-binding l ...
Homo sapiens
Immunology
129
482-495
2010
2
-
-
-
-
-
2
-
-
-
1
4
-
1
-
-
1
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
-
-
-
-
1
4
-
-
-
1
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709084
Venkatraman Girija
Engineering novel complement a ...
Rattus norvegicus
J. Biol. Chem.
285
10546-10552
2010
2
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709160
Skjoedt
A novel mannose-binding lectin ...
Homo sapiens
J. Biol. Chem.
285
8234-8243
2010
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
717934
Kocsis
Selective inhibition of the le ...
Homo sapiens
J. Immunol.
185
4169-4178
2010
-
-
1
-
-
-
4
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
3
-
-
-
-
1
-
-
-
-
-
4
3
-
-
-
-
1
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700247
Swierzko
Mannan-binding lectin-associat ...
Homo sapiens
Mol. Immunol.
46
1696-1701
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700576
Zehnder
Prognosis in pediatric hematol ...
Homo sapiens
Pediatr. Blood Cancer
53
53-57
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709344
Thiel
Polymorphisms in mannan-bindin ...
Homo sapiens
J. Immunol.
182
2939-2947
2009
5
-
-
-
7
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
7
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709348
Phillips
Analogous interactions in init ...
Rattus norvegicus
J. Immunol.
182
7708-7717
2009
3
-
-
-
-
-
-
-
-
-
1
2
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709354
Brouwer
Mannose-binding lectin (MBL) s ...
Homo sapiens
J. Immunol.
183
3496-3504
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709985
Cestari
Role of early lectin pathway a ...
Trypanosoma cruzi
Mol. Immunol.
47
426-437
2009
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
683891
Kerr
Elucidation of the substrate s ...
Homo sapiens
Mol. Immunol.
45
670-677
2008
-
-
-
-
-
-
1
6
-
-
-
3
-
1
-
-
-
-
-
-
-
-
10
-
1
-
-
9
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
6
-
-
-
3
-
-
-
-
-
-
-
-
10
-
1
-
-
9
1
-
-
-
-
-
-
-
-
-
698175
Schafranski
Functional MASP2 gene polymorp ...
Homo sapiens
Hum. Immunol.
69
41-44
2008
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700248
Hamad
Poly(ethylene glycol)s generat ...
Homo sapiens
Mol. Immunol.
46
225-232
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677421
Takahashi
Role of MBL-associated serine ...
Homo sapiens, Mus musculus
Adv. Exp. Med. Biol.
598
93-104
2007
2
-
2
-
2
-
-
-
1
-
-
6
-
3
-
2
-
-
-
2
-
-
11
2
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
2
-
-
-
-
-
1
-
-
6
-
-
2
-
-
2
-
-
11
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680105
Gal
Serine proteases of the classi ...
Homo sapiens, Rattus norvegicus
Immunobiology
212
267-277
2007
-
-
2
1
-
-
5
-
-
2
-
6
-
2
-
3
-
-
-
-
-
-
8
4
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
5
-
-
-
2
-
6
-
-
3
-
-
-
-
-
8
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680169
Moller-Kristensen
Cooperation between MASP-1 and ...
Homo sapiens
Int. Immunol.
19
141-149
2007
1
-
1
-
1
-
-
-
1
-
-
2
-
1
-
-
1
-
-
2
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
1
-
2
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
681205
Teillet
Identification of the site of ...
Homo sapiens
J. Immunol.
178
5710-5716
2007
-
-
1
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682852
Weiss
A novel mannose-binding lectin ...
Homo sapiens
Scand. J. Immunol.
65
430-434
2007
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683124
Unterberger
Stat3 is involved in control o ...
Homo sapiens, Mus musculus, Rattus norvegicus
Biochem. Biophys. Res. Commun.
364
1022-1025
2007
-
-
3
-
1
-
-
-
-
-
-
-
-
6
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683500
Sorensen
Genetic influences on mannan-b ...
Homo sapiens
Genet. Epidemiol.
31
31-41
2007
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
1
1
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
1
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
683524
Wallis
Interactions between mannose-b ...
Homo sapiens
Immunobiology
212
289-299
2007
1
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683739
Girija
Localization and characterizat ...
Rattus norvegicus
J. Immunol.
179
455-462
2007
1
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
683743
Walsh
Fluorochrome-linked immunoassa ...
Homo sapiens
J. Immunol. Methods
323
147-159
2007
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683990
Krarup
Simultaneous activation of com ...
Rattus norvegicus
PLoS ONE
2
e623
2007
-
-
1
-
2
-
-
-
-
1
-
6
-
1
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
1
-
6
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684060
Ytting
Biological variation in circul ...
Homo sapiens
Scand. J. Immunol.
66
458-464
2007
-
1
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665232
Verma
Clinical significance of manno ...
Homo sapiens
Int. J. Cancer
118
2930-2935
2006
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
3
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
683731
Nakao
Lectin pathway of bony fish co ...
Cyprinus carpio
J. Immunol.
177
5471-5479
2006
-
-
1
-
-
-
-
-
-
1
-
2
-
6
-
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
683732
Iwaki
Small mannose-binding lectin-a ...
Mus musculus
J. Immunol.
177
8626-8632
2006
2
-
-
-
1
-
-
-
1
1
-
3
-
1
-
-
-
-
1
1
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
1
1
-
3
-
-
-
-
1
1
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
683927
Mayilyan
Increased complement classical ...
Homo sapiens
Neurosci. Lett.
404
336-341
2006
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659586
Iwaki
Production and purification of ...
Mus musculus
J. Endotoxin Res.
11
47-50
2005
-
-
1
-
1
-
-
-
-
2
2
1
-
1
-
1
-
-
-
-
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
2
2
1
-
-
1
-
-
-
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
665655
Gal
A true autoactivating enzyme. ...
Homo sapiens
J. Biol. Chem.
280
33435-33444
2005
-
-
1
1
1
-
1
2
-
-
1
-
-
1
-
-
1
-
-
-
-
-
2
1
-
-
2
2
-
-
1
-
-
1
-
-
-
1
-
1
1
-
-
1
-
2
-
-
1
-
-
-
-
1
-
-
-
-
2
1
-
-
2
2
-
-
1
1
-
-
-
-
-
-
665686
Rossi
Functional characterization of ...
Homo sapiens
J. Biol. Chem.
280
41811-41818
2005
-
-
1
-
2
-
-
6
-
-
2
-
-
1
-
-
1
-
-
-
-
-
2
2
-
-
-
6
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
6
-
-
2
-
-
-
-
1
-
-
-
-
2
2
-
-
-
6
-
-
-
-
-
-
-
-
-
-
665916
Teillet
The Two Major Oligomeric Forms ...
Homo sapiens
J. Immunol.
174
2870-2877
2005
-
-
1
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666927
Sorensen
Mannan-binding-lectin-associat ...
Homo sapiens, Rattus norvegicus
Semin. Immunopathol.
27
299-319
2005
-
-
2
2
1
-
1
-
2
2
4
-
-
2
-
-
-
-
-
4
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
1
-
-
1
-
-
2
2
4
-
-
-
-
-
-
4
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666963
Lozano
Novel MASP2 variants detected ...
Homo sapiens
Tissue Antigens
66
131-135
2005
-
-
-
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659350
Chen
Two mechanisms for mannose-bin ...
Rattus norvegicus
J. Biol. Chem.
279
26058-26065
2004
1
-
-
-
1
-
1
1
1
-
-
2
-
1
-
2
1
1
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
1
1
-
-
2
-
-
2
1
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659718
Harmat
The structure of MBL-associate ...
Homo sapiens
J. Mol. Biol.
342
1533-1546
2004
-
-
1
1
-
-
1
1
-
1
-
2
-
2
-
2
1
1
-
-
-
-
5
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
1
-
1
-
2
-
-
2
1
-
-
-
-
5
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
659959
Presanis
Differential substrate and inh ...
Homo sapiens
Mol. Immunol.
40
921-929
2004
-
-
-
-
-
1
4
-
1
2
-
3
-
1
-
-
-
-
-
1
1
1
8
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
1
2
-
3
-
-
-
-
-
1
1
1
8
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
650997
Feinberg
Crystal structure of the CUB1- ...
Rattus norvegicus
EMBO J.
22
2348-2359
2003
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
1
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652684
Ambrus
Natural substrates and inhibit ...
Homo sapiens
J. Immunol.
170
1374-1382
2003
-
-
1
-
-
-
2
2
-
-
-
2
-
1
-
-
1
-
-
-
-
-
7
-
-
-
-
2
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
2
1
2
-
-
-
2
-
-
-
1
-
-
-
-
7
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
659629
Moller-Kristensen
Levels of mannan-binding lecti ...
Homo sapiens
J. Immunol. Methods
282
159-167
2003
-
-
-
-
-
-
-
-
-
-
2
3
-
1
-
-
-
-
-
3
-
2
5
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
3
-
-
-
-
-
3
-
2
5
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
652683
Cseh
Characterization of the intera ...
Homo sapiens
J. Immunol.
169
5735-5743
2002
-
-
-
-
-
-
-
-
-
-
3
2
-
1
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
2
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652143
Chen
Stoichiometry of complexes bet ...
Homo sapiens
J. Biol. Chem.
276
25894-25902
2001
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652189
Rossi
Substrate specificities of rec ...
Homo sapiens
J. Biol. Chem.
276
40880-40887
2001
-
-
1
-
-
-
2
6
-
-
-
1
-
1
-
-
1
-
-
-
-
-
8
-
-
-
-
6
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
6
-
-
-
1
-
-
-
1
-
-
-
-
8
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
652677
Thielens
Interaction properties of huma ...
Homo sapiens
J. Immunol.
166
5068-5077
2001
-
-
1
-
-
-
-
-
-
-
1
1
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652674
Matsushita
Proteolytic activities of two ...
Homo sapiens
J. Immunol.
165
2637-2642
2000
-
-
-
-
-
-
1
-
-
-
1
1
-
1
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653250
Wong
Activities of the MBL-associat ...
Homo sapiens
Mol. Immunol.
36
853-861
1999
-
-
-
-
-
-
2
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653331
Thiel
A second serine protease assoc ...
Homo sapiens
Nature
386
506-510
1997
-
-
1
-
-
-
-
-
-
-
4
1
-
1
-
1
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
4
1
-
-
1
1
-
1
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
659609
Matsushita
Activation of the classical co ...
Homo sapiens
J. Exp. Med.
176
1497-1502
1992
-
-
-
-
-
-
-
-
1
-
2
3
-
2
-
-
1
1
1
1
-
-
4
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
3
-
-
-
1
1
1
-
-
4
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-