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Literature summary for 3.4.19.16 extracted from

  • Geu-Flores, F.; Moldrup, M.E.; Boettcher, C.; Olsen, C.E.; Scheel, D.; Halkier, B.A.
    Cytosolic gamma-glutamyl peptidases process glutathione conjugates in the biosynthesis of glucosinolates and camalexin in Arabidopsis (2011), Plant Cell, 23, 2456-2469 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.19.16

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Arabidopsis thaliana 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(E)-1-(glutathion-S-yl)-N-hydroxy-2-(1H-indol-3-yl)ethan-1-imine + H2O Arabidopsis thaliana
-
 (E)-1-(L-cysteinylglycin-S-yl)-N-hydroxy-2-(1H-indol-3-yl)ethan-1-imine + L-glutamate
-
 ?
(glutathion-S-yl)(1H-indol-3-yl)acetonitrile + H2O Arabidopsis thaliana
-
 (L-cysteinylglycin-S-yl)(1H-indol-3-yl)acetonitrile + L-glutamate
-
 ?
additional information Arabidopsis thaliana both GGP1 and GGP3 are able to metabolize nine out of 10 glucosinolate-related GSH conjugates to the corresponding enzymatic products (Cys-Gly conjugates), all of which spontaneously rearrange to their cyclized forms ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9M0A5
-
-
Arabidopsis thaliana Q9M0A7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information high expression in all tissues Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E)-1-(glutathion-S-yl)-N-hydroxy-2-(1H-indol-3-yl)ethan-1-imine + H2O
-
 Arabidopsis thaliana (E)-1-(L-cysteinylglycin-S-yl)-N-hydroxy-2-(1H-indol-3-yl)ethan-1-imine + L-glutamate
-
 ?
(glutathion-S-yl)(1H-indol-3-yl)acetonitrile + H2O
-
 Arabidopsis thaliana (L-cysteinylglycin-S-yl)(1H-indol-3-yl)acetonitrile + L-glutamate
-
 ?
additional information both GGP1 and GGP3 are able to metabolize nine out of 10 glucosinolate-related GSH conjugates to the corresponding enzymatic products (Cys-Gly conjugates), all of which spontaneously rearrange to their cyclized forms Arabidopsis thaliana ?
-
 ?

Synonyms

Synonyms Comment Organism
gamma-glutamyl peptidase 1
-
 Arabidopsis thaliana
gamma-glutamyl peptidase 3
-
 Arabidopsis thaliana
GGP1
-
 Arabidopsis thaliana
GGP3
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function an Arabidopsis thaliana mutant impaired in the production of the gamma-glutamyl peptidases GGP1 and GGP3 has altered glucosinolate levels and accumulates up to 10 related GSH conjugates. The double mutant is impaired in the production of camalexin and accumulates high amounts of the camalexin intermediate GS-indole-3-acetonitrile upon induction Arabidopsis thaliana
physiological function an Arabidopsis thaliana mutant impaired in the production of the gamma-glutamyl peptidases GGP1 and GGP3 has altered glucosinolate levels and accumulates up to 10 related GSH conjugates. The double mutant is impaired in the production of camalexin and accumulates high amounts of the camalexin intermediate GS-indole-3-acetonitrile upon induction. In a GGP1 knockdown mutant, the levels of the different glucosinolates are unaltered in 3-week-old rosette leaves Arabidopsis thaliana