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Literature summary for 3.4.19.13 extracted from

  • Wisnewski, A.V.; Liu, J.; Nassar, A.F.
    In vitro cleavage of diisocyanate-glutathione conjugates by human gamma-glutamyl transpeptidase-1 (2016), Xenobiotica, 46, 726-732 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.19.13

Organism

Organism UniProt Comment Textmining
Homo sapiens P19440
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-linked bis-GSH conjugate of 1,6-hexamethylene diisocyanate + H2O
-
 Homo sapiens bis(Cys-Gly)-1,6-hexamethylene diisocyanate + 2 L-glutamate
-
 ?
S-linked bis-GSH conjugate of 4,4'-methylene diphenyl diisocyanate + H2O
-
 Homo sapiens bis(Cys-Gly)-4,4'-methylene diphenyl diisocyanate + 2 L-glutamate
-
 ?
S-linked mono-GSH conjugate of 1,6-hexamethylene diisocyanate + H2O
-
 Homo sapiens (Cys-Gly)-1,6-hexamethylene diisocyanate + L-glutamate
-
 ?
S-linked mono-GSH conjugate of 4,4'-methylene diphenyl diisocyanate + H2O
-
 Homo sapiens (Cys-Gly)-4,4'-methylene diphenyl diisocyanate + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
GGT-1
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism capacity of the enzyme to cleave GSH conjugates of both aromatic and aliphatic diisocyanates, suggesting a potential role in their metabolism Homo sapiens
metabolism primary enzyme of the mercapturic acid pathway Homo sapiens