Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acivicin | inhibition of gamma-glutamyltranspeptidase by acivicin causes extensive loss of intracellular glutathione from ARL-16T2 cells, which show a high level of gamma-glutamyl transpeptidase, but produces no effect on glutathione levels in ARL-15C1 cells, which show a low level of gamma-glutamyl transpeptidase. Acivicin treatment causes a transient increase in intracellular glutathione in the ARL-16T2 but not the ARL-15C1 cells | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ARL-15C1 cell | nontumorigenic cell line, low level of gamma-glutamyltranspeptidase | Rattus norvegicus | - |
ARL-16T2 cell | tumorigenic cell line, high level of gamma-glutamyl transpeptidase | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
gamma-glutamyl transpeptidase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | inhibition of gamma-glutamyltranspeptidase by acivicin causes extensive loss of intracellular glutathione from ARL-16T2 cells, which show a high level of gamma-glutamyl transpeptidase, but produces no effect on glutathione levels in ARL-15C1 cells, which show a low level of gamma-glutamyl transpeptidase. Acivicin treatment causes a transient increase in intracellular glutathione in the ARL-16T2 but not the ARL-15C1 cells, further suggesting that the enzyme catalyzes intracellular glutathione recycling to supply cysteine for cellular functions in the tumorigenic ARL-16T2 cell line | Rattus norvegicus |