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Literature summary for 3.4.19.13 extracted from

  • Grillo, M.P.; Hua, F.; March, K.L.; Benet, L.Z.; Knutson, C.G.; Ware, J.A.
    Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat (2008), Chem. Res. Toxicol., 21, 1933-1938.
    View publication on PubMed
Search for more literature for 3.4.19.13

Application

Application Comment Organism
medicine treatment of rats with diclofenac results in accumulation of diclofenac-N-acyl-cysteinylglycine and diclofenac-N-acyl-cysteine in bile, albeit only about 1% of the administered dose of diclofenac within 6 h Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
diclofenac-S-acyl-glutathione competitive Bos taurus
diclofenac-S-acyl-glutathione competitive Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0457
-
 diclofenac-S-acyl-glutathione pH 7.4, 37°C Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Bos taurus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diclofenac-S-acyl-glutathione + H2O
-
 Rattus norvegicus diclofenac-S-acyl-L-cysteinylglycine + L-glutamate
-
 ?
diclofenac-S-acyl-glutathione + H2O
-
 Bos taurus diclofenac-S-acyl-L-cysteinylglycine + L-glutamate
-
 ?