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Literature summary for 3.4.19.1 extracted from

  • Zeng, Z.; Rulten, S.; Breslin, C.; Zlatanou, A.; Coulthard, V.; Caldecott, K.
    Acylpeptide hydrolase is a component of the cellular response to DNA damage (2017), DNA Repair, 58, 52-61 .
    View publication on PubMed
Search for more literature for 3.4.19.1

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
additional information APEH is primarily localised in the cytoplasm, but a subfraction of the enzyme is sequestered at sites of nuclear damage following UVA irradiation or following oxidative stress Homo sapiens
-
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens APEH interacts with the amino-terminal domain of XRCC1 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P13798
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information APEH interacts with the amino-terminal domain of XRCC1 Homo sapiens ?
-
 ?
additional information acylpeptide hydrolase (APEH) deacetylates N-alpha-acetylated peptides and selectively degrades oxidised protein Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
acylpeptide hydrolase
-
 Homo sapiens
APEH
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme APEH is a component of the cellular response to DNA damage. APEH is primarily localised in the cytoplasm, but a subfraction of the enzyme is sequestered at sites of nuclear damage following UVA irradiation or following oxidative stress. Localization of APEH at sites of nuclear damage is mediated by direct interaction with XRCC1, a scaffold protein that accelerates the repair of DNA single-strand breaks. APEH interacts with the amino-terminal domain of XRCC1, and APEH facilitates both single-strand break repair and cell survival following exposure to H2O2 in human cells Homo sapiens