Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
methotrexate + H2O | Pseudomonas sp. | related toxicity, overview, rapid inactivation of methotrexate by CPDG2, the product DAMPA is eliminated more raoidly than methotrexate | 4-[(2,4-diamino-6-(pteridinyl)methyl)-methylamino]-benzoic acid + L-glutamate | i.e. DAMPA | ? | |
additional information | Pseudomonas sp. | effects of carboxypeptidase G2 administration to patients with methotrexate-induce renal failure, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas sp. | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant enzyme | Pseudomonas sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6R,S)-leucovorin + H2O | - |
Pseudomonas sp. | N-(6R,S)-5-formyl-5,6,7,8-tetrahydropteroic acid + L-glutamate | - |
? | |
methotrexate + H2O | - |
Pseudomonas sp. | 4-[(2,4-diamino-6-(pteridinyl)methyl)-methylamino]-benzoic acid + L-glutamate | - |
? | |
methotrexate + H2O | related toxicity, overview, rapid inactivation of methotrexate by CPDG2, the product DAMPA is eliminated more raoidly than methotrexate | Pseudomonas sp. | 4-[(2,4-diamino-6-(pteridinyl)methyl)-methylamino]-benzoic acid + L-glutamate | i.e. DAMPA | ? | |
additional information | effects of carboxypeptidase G2 administration to patients with methotrexate-induce renal failure, overview | Pseudomonas sp. | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxypeptidase G2 | - |
Pseudomonas sp. |
CPDG2 | - |
Pseudomonas sp. |