Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.17.10 extracted from

  • Zhou, A.; Minami, M.; Zhu, X.; Bae, S.; Minthorne, J.; Lan, J.; Xiong, Z.G.; Simon, R.P.
    Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication (2004), J. Cereb. Blood Flow Metab., 24, 612-622.
    View publication on PubMed
Search for more literature for 3.4.17.10

Protein Variants

Protein Variants Comment Organism
additional information a spontaneous Cpefat/fat mutant strain produces an inactive enzyme, which results in diminished cell survival after ischemic stress in the brain in vivo and in neuronal cells in vitro, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus altered biosynthesis of the neuropeptide processing enzyme after brain ischemia: molecular mechanism and implication ?
-
 ?
additional information Rattus norvegicus altered biosynthesis of the neuropeptide processing enzyme after brain ischemia: molecular mechanism and implication ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
 male sprague-dawley rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein alterations in the glycosylation status of the enzyme during ischemia, unprocessed pro-enzyme accumulates in cortical neurons after ischemia Rattus norvegicus
proteolytic modification the 55 kDa proenzyme is processed to the 53 kDa mature protein Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte cell culture Mus musculus
-
astrocyte cell culture Rattus norvegicus
-
brain
-
 Mus musculus
-
brain cortex and striatum Rattus norvegicus
-
additional information unprocessed pro-enzyme accumulates in cortical neurons after ischemia Rattus norvegicus
-
neuron
-
 Rattus norvegicus
-
neuron cortical, culture Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information altered biosynthesis of the neuropeptide processing enzyme after brain ischemia: molecular mechanism and implication Mus musculus ?
-
 ?
additional information altered biosynthesis of the neuropeptide processing enzyme after brain ischemia: molecular mechanism and implication Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 53000-59000, different enzyme forms, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
CPE
-
 Mus musculus
CPE
-
 Rattus norvegicus