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Literature summary for 3.4.17.1 extracted from

  • Testero, S.A.; Granados, C.; Fernandez, D.; Gallego, P.; Covaleda, G.; Reverter, D.; Vendrell, J.; Aviles, F.X.; Pallares, I.; Mobashery, S.
    Discovery of mechanism-based inactivators for human pancreatic carboxypeptidase A from a focused synthetic library (2017), ACS Med. Chem. Lett., 8, 1122-1127 .
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitor 4-methyl-2-[(2R)-thiiran-2-yl]pentanoic acid Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-methyl-2-[(2R)-thiiran-2-yl]pentanoic acid mechanism-based inhibitor Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc zinc enzyme, the zinc coordination number is five in the complex with the inhibitor 4-methyl-2-[(2R)-thiiran-2-yl]pentanoic acid and the resulting geometry is tetrahedral Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15085
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(4-methoxyphenylazoformyl)-Phe + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CPA1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.056
-
 pH 7.5, 37°C Homo sapiens 4-methyl-2-[(2R)-thiiran-2-yl]pentanoic acid