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Literature summary for 3.4.15.1 extracted from

  • Reis, R.I.; Nogueira, M.D.; Campanha-Rodrigues, A.L.; Pereira, L.M.; Andrade, M.C.C.; Parreiras-E-Silva, L.T.; Costa-Neto, C.M.; Mortara, R.A.; Casarini, D.E.
    The binding of captopril to angiotensin I-converting enzyme triggers activation of signaling pathways (2018), Am. J. Physiol. Cell Physiol., 315, C367-C379 .
    View publication on PubMed
Search for more literature for 3.4.15.1

Application

Application Comment Organism
medicine hypertension is a global health problem, and angiotensin I (ANG I)-converting enzyme (ACE) inhibitors are largely used to control this pathology Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
stable recombinant expression of ACE in CHO cells and quantitative real-time RT-PCR expression analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus ACE interacts with beta-arrestin1 ?
-
 ?
additional information Rattus norvegicus Wistar ACE interacts with beta-arrestin1 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P47820 wild-type Wistar and spontaneously hypertensive rats (SHR) derived thereof
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Rattus norvegicus Wistar P47820 wild-type Wistar and spontaneously hypertensive rats (SHR) derived thereof
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Source Tissue

Source Tissue Comment Organism Textmining
mesangial cell primary Rattus norvegicus
-
additional information ACE colocalizes with beta-arrestin1 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ACE interacts with beta-arrestin1 Rattus norvegicus ?
-
 ?
additional information ACE interacts with beta-arrestin1 Rattus norvegicus Wistar ?
-
 ?

Synonyms

Synonyms Comment Organism
ACE
-
 Rattus norvegicus
ANG I-converting enzyme
-
 Rattus norvegicus
angiotensin I-converting enzyme
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction inhibition of ACE leads to amelioration of endothelial function, vascular remodeling, and reduction in atherosclerosis progression Rattus norvegicus
additional information ACE colocalizes with beta-arrestin1 Rattus norvegicus
physiological function binding of captopril to angiotensin I-converting enzyme triggers activation of signaling pathways via JNK and ERK1/2 phosphorylation. Captopril leads to gene modulation trough binding to ACE causing a decrease of COX2 expression and an increase of AP2 expression. ACE interacts with beta-arrestin1, and this interaction seems to increase under captopril stimulation in CHO-ACE cells Rattus norvegicus