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Literature summary for 3.4.14.5 extracted from

  • Ge, J.; Feng, Y.; Ji, H.; Zhang, H.; Zheng, F.; Wang, C.; Yin, Z.; Pan, X.; Tang, J.
    Inactivation of dipeptidyl peptidase IV attenuates the virulence of Streptococcus suis serotype 2 that causes streptococcal toxic shock syndrome (2009), Curr. Microbiol., 59, 248-255.
    View publication on PubMed
Search for more literature for 3.4.14.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Streptococcus suis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
 Gly-L-Pro-4-nitroanilide at pH 8.0 and 37°C Streptococcus suis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
87000
-
 calculated from amino acid sequence Streptococcus suis
105000
-
 recombinant DPP IV protein fused with an N-terminal His-tag and thioredoxin-tag Streptococcus suis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptococcus suis dipeptidyl peptidase IV is a serine protease that cleaves X-Pro/Ala dipeptide from the N-terminus of proteins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus suis
-
 serotype 2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-L-Pro-4-nitroanilide + H2O
-
 Streptococcus suis Gly-L-Pro + 4-nitroaniline
-
 ?
additional information dipeptidyl peptidase IV is a serine protease that cleaves X-Pro/Ala dipeptide from the N-terminus of proteins Streptococcus suis ?
-
 ?

Synonyms

Synonyms Comment Organism
CD26
-
 Streptococcus suis
dipeptidyl peptidase IV
-
 Streptococcus suis
DPP IV
-
 Streptococcus suis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Streptococcus suis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
 20% of the enzyme activity remains after incubation at 50°C for 30 min Streptococcus suis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Streptococcus suis

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.5
-
 Streptococcus suis

General Information

General Information Comment Organism
physiological function DPP IV contributes to virulence of streptococcal toxic shock syndrome-causing Streptococcus suis serotype 2 Streptococcus suis