Cloned (Comment) | Organism |
---|---|
expression of the enzyme, tagged with either HA-tag or Myc-tag, in 293T cells, expressio of mutant enzymes in Escherichia coli XL1-Blue | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction and expression of leucine zipper mutants and active site mutants, the former show no remaining activity, while the latter are not catalytically active but are still able to dimerize | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | secretion | Homo sapiens | - |
- |
intracellular | - |
Homo sapiens | 5622 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
2 * 58000, homodimerization via leucine zipper motif is required for activity, the active site is not required for dimerization | Homo sapiens |
120000 | 130000 | gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
hydrolysis of Xaa-/-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro | the enzyme cleaves N-terminal Xaa-Pro dipeptides from proteins | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-Pro-amino-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | alanine + Pro-4-trifluoromethylcoumarin | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 58000, homodimerization via leucine zipper motif is required for activity, the active site is not required for dimerization | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
More | enzyme belongs to the methionyl amino peptidase family M24, fomerly EC 3.4.3.7 | Homo sapiens |
QPP | - |
Homo sapiens |
quiescent cell proline dipeptidase | - |
Homo sapiens |