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Literature summary for 3.4.13.20 extracted from

  • Sauerhoefer, S.; Yuan, G.; Braun, G.S.; Deinzer, M.; Neumaier, M.; Gretz, N.; Floege, J.; Kriz, W.; van der Woude, F.; Moeller, M.J.
    L-carnosine, a substrate of carnosinase-1, influences glucose metabolism (2007), Diabetes, 56, 2425-2432.
    View publication on PubMed
Search for more literature for 3.4.13.20

Application

Application Comment Organism
medicine liver-specific expression of enzyme in db/db mice, a model of type 2 diabetes. Transgenic mice shows reduced body weight as a result of glucosuria. Fasting plasma glucose as well as hemoglobin A1C levels rise earlier and remain higher throughout their life than in control animals. Serum fasting insulin levels are low and elevated by L-carnosine feeding. Insulin resistance and insulin secretion are not significantly affected by L-carnosine serum levels. Instead, a significant correlation of L-carnosine levels with beta-cell mass is observed Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in db/db mice, a model of type 2 diabetes Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information liver-specific expression of enzyme in db/db mice, a model of type 2 diabetes. Transgenic mice shows reduced body weight as a result of glucosuria. Fasting plasma glucose as well as hemoglobin A1C levels rise earlier and remain higher throughout their life than in control animals. Serum fasting insulin levels are low and elevated by L-carnosine feeding. Insulin resistance and insulin secretion are not significantly affected by L-carnosine serum levels. Instead, a significant correlation of L-carnosine levels with beta-cell mass is observed Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
carnosinase-1
-
 Homo sapiens