Activating Compound | Comment | Organism | Structure |
---|---|---|---|
citrate | activates | Homo sapiens | |
phosphate | activates | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by p-hydroxymercuribenzoate, CH2ClCOONa, phenylmethylsulfonyl fluoride | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | activates, twice as effective as Mn2+, maximum activity at 0.8-0.9 mM | Homo sapiens | |
Mn2+ | activates, less effective than Cd2+ | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
160000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
little or no activity in children below 10 months in age thereafter, the average concentration increases gradually to reach the adult range at the age 13-15 | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood serum | concentration varies greatly between individuals | Homo sapiens | - |
Storage Stability | Organism |
---|---|
-80°C, stable for several weeks in serum | Homo sapiens |
4°C, stable for a day or two in serum | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
carnosine + H2O | beta-Ala-His | Homo sapiens | beta-Ala + His | - |
? | |
homocarnosine + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | no hydrolysis of L-Ala-His, Gly-His or N-acetylhistidine | Homo sapiens | ? | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
30 min, pH 7.8, stable, thermostability improved by the presence of 0.25 mM MnCl2, stability is very poor in the presence of 0.25 mM cadmium or calcium | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.7 | - |
- |
Homo sapiens |
8 | 8.5 | - |
Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.2 | maximal stability at 50°C | Homo sapiens |