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Literature summary for extracted from

  • Drinkwater, N.; Bamert, R.S.; Kannan Sivaraman, K.; Paiardini, A.; McGowan, S.
    X-ray crystal structures of an orally available aminopeptidase inhibitor, tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17 (2015), Proteins, 83, 789-795.
    View publication on PubMed


Cloned (Comment) Organism
expression in Escherichia coli Plasmodium falciparum

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitor tosedostat. The inhibitor occupies the enzymes' putative product egress channels in addition to the substrate binding pockets. Inhibitor adopts different binding poses when bound to isoforms M1, and M17 Plasmodium falciparum


Inhibitors Comment Organism Structure
tosedostat i.e. (2S)-([(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino)(phenyl)ethanoic acid, crystal structure; i.e. (2S)-({(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}amino)(phenyl)ethanoic acid, crystal structure Plasmodium falciparum


Organism UniProt Comment Textmining
Plasmodium falciparum O96935
Plasmodium falciparum Q8IL11
Plasmodium falciparum isolate FcB1/Columbia O96935


Synonyms Comment Organism
aminopeptidase M17
Plasmodium falciparum
M1 aminopeptidase
Plasmodium falciparum