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Literature summary for 3.4.11.2 extracted from

  • Quesada, A.; Segarra, A.B.; Montoro-Molina, S.; de Gracia, M.D.; Osuna, A.; O'Valle, F.; Gomez-Guzman, M.; Vargas, F.; Wangensteen, R.
    Glutamyl aminopeptidase in microvesicular and exosomal fractions of urine is related with renal dysfunction in cisplatin-treated rats (2017), PLoS ONE, 12, e0175462 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.11.2

Application

Application Comment Organism
diagnostics determination of AlaAp content or its enzymatic activity in microvesicular and exosomal fractions of urine is an early and predictive biomarker of renal dysfunction in cisplatin-induced nephrotoxicity. Nephrotoxic effect of cisplatin over tubular epithelia can be assessed independently of creatinine status or diuresis, overview. It might also be a very useful marker in pathologies where evaluation of early tubular damage takes relevance Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular in microvesicular and exosomal fractions of urine Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P15684
-
-
Rattus norvegicus Wistar P15684
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
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urine in microvesicular and exosomal fractions Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanyl-2-naphthylamide + H2O
-
 Rattus norvegicus L-alanine + 2-naphthylamine
-
 ?
L-alanyl-2-naphthylamide + H2O
-
 Rattus norvegicus Wistar L-alanine + 2-naphthylamine
-
 ?

Synonyms

Synonyms Comment Organism
AlaAP
-
 Rattus norvegicus
alanyl aminopeptidase
-
 Rattus norvegicus
ENPEP
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.7
-
 assay at Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus increase of AlaAp in microvesicular and exosomal fractions from cisplatin-treated rats up

General Information

General Information Comment Organism
physiological function an early high increase in the excretion or activity of the enzyme in supernatant of urine from cisplatin-treated rats are correlated with the extent of renal damage Rattus norvegicus