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Literature summary for 3.4.11.2 extracted from

  • Weglarz-Tomczak, E.; Berlicki, L.; Pawelczak, M.; Nocek, B.; Joachimiak, A.; Mucha, A.
    A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases (2016), Eur. J. Med. Chem., 117, 187-196 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.11.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens
-
 Neisseria meningitidis serogroup B

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitors [1-amino-2-(cyclohexylamino)ethyl]phosphonic acid and (1-amino-2-anilinoethyl)phosphonic acid Neisseria meningitidis serogroup B

Inhibitors

Inhibitors Comment Organism Structure
(1-amino-2-anilinoethyl)phosphonic acid
-
 Homo sapiens
(1-amino-2-anilinoethyl)phosphonic acid
-
 Neisseria meningitidis serogroup B
(1-amino-2-[[(4-methoxyphenyl)methyl]amino]ethyl)phosphonic acid
-
 Homo sapiens
(1-amino-2-[[(4-methoxyphenyl)methyl]amino]ethyl)phosphonic acid
-
 Neisseria meningitidis serogroup B
[1-amino-2-(cyclohexylamino)ethyl]phosphonic acid
-
 Homo sapiens
[1-amino-2-(cyclohexylamino)ethyl]phosphonic acid
-
 Neisseria meningitidis serogroup B

Organism

Organism UniProt Comment Textmining
Homo sapiens P15144
-
-
Neisseria meningitidis serogroup B Q9JYV4
-
-
Neisseria meningitidis serogroup B MC58 Q9JYV4
-
-

Synonyms

Synonyms Comment Organism
ANPEP
-
 Homo sapiens
APN
-
 Homo sapiens
APN
-
 Neisseria meningitidis serogroup B
PepN
-
 Neisseria meningitidis serogroup B

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000065
-
 (1-amino-2-[[(4-methoxyphenyl)methyl]amino]ethyl)phosphonic acid pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.000341
-
 (1-amino-2-anilinoethyl)phosphonic acid pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00069
-
 [1-amino-2-(cyclohexylamino)ethyl]phosphonic acid pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00233
-
 (1-amino-2-[[(4-methoxyphenyl)methyl]amino]ethyl)phosphonic acid pH not specified in the publication, temperature not specified in the publication Neisseria meningitidis serogroup B
0.00238
-
 [1-amino-2-(cyclohexylamino)ethyl]phosphonic acid pH not specified in the publication, temperature not specified in the publication Neisseria meningitidis serogroup B
0.0166
-
 (1-amino-2-anilinoethyl)phosphonic acid pH not specified in the publication, temperature not specified in the publication Neisseria meningitidis serogroup B