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Literature summary for 3.4.11.14 extracted from
- Human liver alanine aminopeptidase. Inhibition by amino acids (1975), Biochemistry, 14, 3208-3212.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ala-Ala | inhibits hyrolysis of Ala-2-naphthylamide | Homo sapiens |  |
| Ala-Ala-Ala | inhibits hyrolysis of Ala-2-naphthylamide | Homo sapiens | |
| Ala-Ala-Ala-Ala | inhibits hyrolysis of Ala-2-naphthylamide | Homo sapiens | |
| Gly-Gly-Ala | inhibits hyrolysis of Ala-4-nitroanilide | Homo sapiens | |
| Gly-Gly-Phe | inhibits hyrolysis of Ala-4-nitroanilide | Homo sapiens | |
| Leu | noncompetitive with Ala-2-naphthylamide, mixed type inhibition with Leu-Leu-Leu, competitive inhibition with Ala-Ala-Ala | Homo sapiens | |
| Leu-Leu | - |
Homo sapiens | |
| Leu-Leu-Leu | inhibits hyrolysis of Ala-2-naphthylamide | Homo sapiens | |
| Met | noncompetitive with Ala-2-naphthylamide | Homo sapiens | |
| Met-NH2 | competitive with Ala-2-naphthylamide | Homo sapiens | |
| Phe | noncompetitive with Ala-2-naphthylamide | Homo sapiens | |
| Tyr | noncompetitive with Ala-2-naphthylamide, competitive with Ala-Ala-Ala | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 70 | - |
hydrolysis of L-alanyl-2-naphthylamide | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala-2-naphthylamide + H2O | - |
Homo sapiens | Ala + 2-naphthylamine | - |
? | |
| Leu-Leu + H2O | - |
Homo sapiens | Leu + Leu | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.054 | - |
Leu-Leu-Leu | hydrolysis of Ala-2-naphthylamide | Homo sapiens | |
| 0.089 | - |
Ala-Ala-Ala-Ala | hydrolysis of Ala-2-naphthylamide | Homo sapiens | |
| 0.23 | - |
Leu-Leu | hydrolysis of Ala-2-naphthylamide | Homo sapiens | |
| 0.32 | - |
Ala-Ala-Ala | hydrolysis of Ala-4-nitroanilide | Homo sapiens | |
| 1.4 | - |
Gly-Gly-Phe | hydrolysis of Ala-4-nitroanilide | Homo sapiens | |
| 1.9 | - |
Ala-Ala | hydrolysis of Ala-2-naphthylamide | Homo sapiens | |
| 7 | - |
Gly-Gly-Ala | hydrolysis of Ala-2-naphthylamide | Homo sapiens | |
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Release 2023.1 (January 2023)
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