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Literature summary for 3.3.2.6 extracted from

  • Rusznak, M.; Stokes Peebles, R.
    Eosinophils express LTA4 hydrolase and synthesize LTB4 important for asthma pathogenesis? (2019), Am. J. Respir. Cell Mol. Biol., 60, 375-376 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.6

Application

Application Comment Organism
drug development possible therapeutic potential of targeting LTB4/BLT signaling in asthma, but production of LTB4 may not be responsible for airway neutrophils in severe asthma Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
JNJ 40929837
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + H2O Homo sapiens
-
 leukotriene B4
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09960
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
eosinophil roughly two-thirds of the eosinophil population express 5-lipoxygenase (5-LO), and of those 5-LO-expressing cells, over 99% express both LTA4 hydrolase and LTC4 synthase. Peripheral blood eosinophils cultured in vitro produce LTB4 when unstimulated, and they release significantly elevated levels of LTB4 when stimulated with aspirin-lysine, PMA, and platelet-activating factor Homo sapiens
-
epithelial cell
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?

Synonyms

Synonyms Comment Organism
LTA4 hydrolase
-
 Homo sapiens

General Information

General Information Comment Organism
additional information eosinophils express LTA4 hydrolase and release LTB4. In addition to neutrophils, epithelial cells, and certain phagocytes, eosinophils are classified as contributors to the generation of the inflammatory mediator LTB4. Leukotriene B4 (LTB4) is a potent neutrophil chemoattractant, and this mediator might be an alternative to the Th17 axis as a potential mechanism leading to airway neutrophils. The enzyme might play a role in asthma Homo sapiens