Protein Variants | Comment | Organism |
---|---|---|
additional information | positive correlation between LTA4H polymorphism and the amount of LTB4 produced in vitro by granulocytes from the affected individuals. Heterozygosity at LTA4H is also associated with increased LTB4 production in vivo resulting in enhanced protection from TB or leprosy | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | Homo sapiens | - |
leukotriene B4 | i.e. LTB4, a powerful proinflammatory agent | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
monocyte | - |
Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + H2O | - |
Homo sapiens | leukotriene B4 | - |
? | |
leukotriene A4 + H2O | - |
Homo sapiens | leukotriene B4 | i.e. LTB4, a powerful proinflammatory agent | ? |
Synonyms | Comment | Organism |
---|---|---|
LTA4 hydrolase | - |
Homo sapiens |
LTA4H | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | leukotrienes are involved in antiinflammation via eicosanoids, lipid mediators derived from arachidonic acid including the proinflammatory leukotrienes as well as the anti-inflammatory lipoxins, complex interplay between proinflammatory leukotrienes and antiinflammatory lipoxins. The enzyme is important in the balance between proinflammatory and anti-inflammatory responses in tuberculosis | Homo sapiens |