Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Campylobacter jejuni subsp. jejuni |
Crystallization (Comment) | Organism |
---|---|
free enzyme or in complex with inhibitors, sitting drop vapor diffusion method | Campylobacter jejuni subsp. jejuni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol | - |
Campylobacter jejuni subsp. jejuni | |
(2R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-[(pyrazin-2-yl)sulfanyl]propan-1-ol | - |
Campylobacter jejuni subsp. jejuni | |
(2S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]octan-1-ol | - |
Campylobacter jejuni subsp. jejuni | |
(2S,3S,4R,5S)-2-(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]pyrrolidine-3,4-diol | - |
Campylobacter jejuni subsp. jejuni | |
(2S,3S,4R,5S)-2-(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[[(4-chlorophenyl)sulfanyl]methyl]pyrrolidine-3,4-diol | - |
Campylobacter jejuni subsp. jejuni | |
(2S,3S,4R,5S)-2-(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[[(naphthalen-1-yl)sulfanyl]methyl]pyrrolidine-3,4-diol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4R)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(hydroxymethyl)pyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(adamant-1-yl)sulfanyl]methyl]pyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-([[2-(2-hydroxyethoxy)ethyl]sulfanyl]methyl)pyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-butylpyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-ethylpyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-methylpyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-propylpyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(cyclohexylsulfanyl)methyl]pyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(hexylsulfanyl)methyl]pyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(phenylsulfanyl)methyl]pyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[2-(hexylsulfanyl)ethyl]pyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[[(4-chlorophenyl)sulfanyl]methyl]pyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[[(pyrazin-2-yl)sulfanyl]methyl]pyrrolidin-3-ol | - |
Campylobacter jejuni subsp. jejuni | |
(3S,4R,5R)-2-(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol | - |
Campylobacter jejuni subsp. jejuni | |
(3S,4R,5R)-2-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol | - |
Campylobacter jejuni subsp. jejuni | |
3-(3-[(3S,4R)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-hydroxypyrrolidin-3-yl]propanoyl)benzoic acid | - |
Campylobacter jejuni subsp. jejuni | |
3-[3-[(2R,3R,4S,5S)-5-(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxypyrrolidin-2-yl]propanoyl]benzoic acid | - |
Campylobacter jejuni subsp. jejuni | |
7-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | - |
Campylobacter jejuni subsp. jejuni | |
gentamicin | - |
Campylobacter jejuni subsp. jejuni | |
[(3S,4R)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-hydroxypyrrolidin-3-yl]methionine | - |
Campylobacter jejuni subsp. jejuni |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0035 | - |
6-amino-6-deoxyfutalosine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0071 | - |
5'-methylthioadenosine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0075 | - |
adenosine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0122 | - |
S-5'-adenosyl-L-homocysteine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0214 | - |
5'-deoxyadenosine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Campylobacter jejuni subsp. jejuni | Q0PC20 | - |
- |
Campylobacter jejuni subsp. jejuni ATCC 700819 | Q0PC20 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography | Campylobacter jejuni subsp. jejuni |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-deoxyadenosine + H2O | - |
Campylobacter jejuni subsp. jejuni | ? | - |
? | |
5'-deoxyadenosine + H2O | - |
Campylobacter jejuni subsp. jejuni ATCC 700819 | ? | - |
? | |
5'-methylthioadenosine + H2O | - |
Campylobacter jejuni subsp. jejuni | ? | - |
? | |
5'-methylthioadenosine + H2O | - |
Campylobacter jejuni subsp. jejuni ATCC 700819 | ? | - |
? | |
6-amino-6-deoxyfutalosine + H2O | - |
Campylobacter jejuni subsp. jejuni | dehypoxanthine futalosine + adenine | - |
? | |
6-amino-6-deoxyfutalosine + H2O | - |
Campylobacter jejuni subsp. jejuni ATCC 700819 | dehypoxanthine futalosine + adenine | - |
? | |
adenosine + H2O | - |
Campylobacter jejuni subsp. jejuni | ? | - |
? | |
adenosine + H2O | - |
Campylobacter jejuni subsp. jejuni ATCC 700819 | ? | - |
? | |
S-5'-adenosyl-L-homocysteine + H2O | - |
Campylobacter jejuni subsp. jejuni | ? | - |
? | |
S-5'-adenosyl-L-homocysteine + H2O | - |
Campylobacter jejuni subsp. jejuni ATCC 700819 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5'-methylthioadenosine nucleosidase | - |
Campylobacter jejuni subsp. jejuni |
MTAN | - |
Campylobacter jejuni subsp. jejuni |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.27 | - |
6-amino-6-deoxyfutalosine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.3 | - |
adenosine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.55 | - |
S-5'-adenosyl-L-homocysteine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.8 | - |
5'-methylthioadenosine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.92 | - |
5'-deoxyadenosine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000065 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(hexylsulfanyl)methyl]pyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.00000075 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0000014 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[[(pyrazin-2-yl)sulfanyl]methyl]pyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0000014 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-butylpyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.000002 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[2-(hexylsulfanyl)ethyl]pyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0000022 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(cyclohexylsulfanyl)methyl]pyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0000029 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-propylpyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0000029 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0000031 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[[(4-chlorophenyl)sulfanyl]methyl]pyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0000032 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-([[2-(2-hydroxyethoxy)ethyl]sulfanyl]methyl)pyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.000004 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(phenylsulfanyl)methyl]pyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0000062 | - |
(2S)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]octan-1-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.00001 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-ethylpyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.000014 | - |
(2S,3S,4R,5S)-2-(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]pyrrolidine-3,4-diol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.000019 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(adamant-1-yl)sulfanyl]methyl]pyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.000024 | - |
[(3S,4R)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-hydroxypyrrolidin-3-yl]methionine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.000028 | - |
(2S,3S,4R,5S)-2-(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[[(4-chlorophenyl)sulfanyl]methyl]pyrrolidine-3,4-diol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.000055 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-methylpyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.000106 | - |
3-(3-[(3S,4R)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-hydroxypyrrolidin-3-yl]propanoyl)benzoic acid | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.000216 | - |
(2R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-(methylsulfanyl)propan-1-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.000422 | - |
(2S,3S,4R,5S)-2-(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[[(naphthalen-1-yl)sulfanyl]methyl]pyrrolidine-3,4-diol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.000946 | - |
(2R)-2-[[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino]-3-[(pyrazin-2-yl)sulfanyl]propan-1-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0017 | - |
(3R,4S)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]pyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0026 | - |
(3R,4R)-1-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-(hydroxymethyl)pyrrolidin-3-ol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.0027 | - |
3-[3-[(2R,3R,4S,5S)-5-(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxypyrrolidin-2-yl]propanoyl]benzoic acid | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.013 | - |
(3S,4R,5R)-2-[(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-5-(hydroxymethyl)pyrrolidine-3,4-diol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.014 | - |
(3S,4R,5R)-2-(4-amino-5,7a-dihydro-4aH-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
0.022 | - |
7-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0021 | - |
at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | gentamicin |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
40 | - |
adenosine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
43 | - |
5'-deoxyadenosine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
46 | - |
S-5'-adenosyl-L-homocysteine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
78 | - |
6-amino-6-deoxyfutalosine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni | |
113 | - |
5'-methylthioadenosine | at pH 7.4 and 25°C | Campylobacter jejuni subsp. jejuni |