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Literature summary for 3.2.2.19 extracted from
- Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases (2014), DNA Repair, 23, 88-94.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | isoform ARH1 and ARH3 | Mus musculus | 5737 | - |
| mitochondrion | isoform ARH3 | Mus musculus | 5739 | - |
| nucleus | isoform ARH3 | Mus musculus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | enzymatic activity requires 2 Mg2+ | Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-ribose-arginine + H2O | Mus musculus | - |
ADP-ribose + arginine | - |
? | |
| O-acetyl-ADP-ribose + H2O | Mus musculus | the reaction is catalyzed by isoform ARH3 only | ADP-ribose + acetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-ribose-arginine + H2O | - |
Mus musculus | ADP-ribose + arginine | - |
? | |
| additional information | isoform ARH1 catalyzes the hydrolysis of the N-glycosidic bond of mono-(ADP-ribosyl)ated arginine, while isoform ARH3 hydrolyzes poly-(ADP-ribose) and O-acetyl-ADP-ribose | Mus musculus | ? | - |
? | |
| O-acetyl-ADP-ribose + H2O | the reaction is catalyzed by isoform ARH3 only | Mus musculus | ADP-ribose + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADP-ribosyl-acceptor hydrolase | - |
Mus musculus |
| ARH1 | isoform | Mus musculus |
| ARH3 | isoform | Mus musculus |
| mono-ADP-ribosyl-arginine hydrolase | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | isoform ARH1 is involved in the action by bacterial toxins as well as intumorigenesis. Isoform ARH3 participates in the degradation of poly-(ADP-ribose) that is synthesized by poly-(ADP-ribose) polymerase 1 in response to oxidative stress-induced DNA damage. Isoform ARH1 is involved in estrogen-stimulated tumorigenesis. Isoform ARH3 is involved in the regulation of parthanatos (PARP1-dependent cell death) | Mus musculus |
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Release 2023.1 (January 2023)
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