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Literature summary for 3.2.1.35 extracted from

  • Albeiroti, S.; Ayasoufi, K.; Hill, D.; Shen, B.; De La Motte, C.
    Platelet hyaluronidase-2 An enzyme that translocates to the surface upon activation to function in extracellular matrix degradation (2015), Blood, 125, 1460-1469 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hyaluronan + H2O Homo sapiens human platelets degrade the proinflammatory matrix hyaluronan through the activity of HYAL2 and platelet activation causes the immediate translocation of HYAL2 from a distinct population of alpha-granules to platelet surfaces where it exerts its catalytic activity ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q12891
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet the enzyme translocates to the surface upon activation to function in extracellular matrix degradation Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hyaluronan + H2O
-
 Homo sapiens ?
-
 ?
hyaluronan + H2O human platelets degrade the proinflammatory matrix hyaluronan through the activity of HYAL2 and platelet activation causes the immediate translocation of HYAL2 from a distinct population of alpha-granules to platelet surfaces where it exerts its catalytic activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Hyal2
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 Homo sapiens
hyaluronidase-2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction patients with inflammatory bowel disease have lower platelet HYAL2 levels and activity than healthy controls Homo sapiens
physiological function human platelets degrade the proinflammatory matrix hyaluronan through the activity of HYAL2 and platelet activation causes the immediate translocation of HYAL2 from a distinct population of alpha-granules to platelet surfaces where it exerts its catalytic activity Homo sapiens