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Literature summary for 3.2.1.209 extracted from

  • Mast, S.W.; Moremen, K.W.
    Family 47 alpha-mannosidases in N-glycan processing (2006), Methods Enzymol., 415, 31-46.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.209

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Homo sapiens
expressed in Pichia pastoris Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
D463N binding affinity Homo sapiens
E330Q catalytic mutant, contributes to general acid function Homo sapiens
E599Q general base Homo sapiens
F659A glycone binding affinity, catalysis Homo sapiens
R461A minor contribution to catalysis, glycan binding affinity Homo sapiens
R461L branch specificity/steric hindrance Homo sapiens
R597A minor contribution to catalysis Homo sapiens
T688A Ca2+ tethering, catalysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-deoxymannojirimycin
-
 Homo sapiens
kifunensine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
endoplasmic reticulum
-
 Saccharomyces cerevisiae 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UKM7
-
-
Saccharomyces cerevisiae P32906
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Saccharomyces cerevisiae

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + H2O
-
 Homo sapiens alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + H2O
-
 Saccharomyces cerevisiae alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?

Synonyms

Synonyms Comment Organism
alpha-mannosidase Class 1 mannosidases, CAZy GH family 47 Homo sapiens
alpha-mannosidase Class 1 mannosidases, CAZy GH family 47 Saccharomyces cerevisiae
ERManI
-
 Homo sapiens
ERManI
-
 Saccharomyces cerevisiae