Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.165 extracted from

  • Pluvinage, B.; Ghinet, M.G.; Brzezinski, R.; Boraston, A.B.; Stubbs, K.A.
    Inhibition of the exo-beta-D-glucosaminidase CsxA by a glucosamine-configured castanospermine and an amino-australine analogue (2009), Org. Biomol. Chem., 7, 4169-4172.
    View publication on PubMed
Search for more literature for 3.2.1.165

Inhibitors

Inhibitors Comment Organism Structure
(1R,2R,3R,7S,7aR)-3-(aminomethyl)hexahydro-1H-pyrrolizine-1,2,7-triol modest competitive inhibitor of CsxA Amycolatopsis orientalis
(1S,6S,7R,8R)-6-aminooctahydroindolizine-1,7,8-triol potent competitive inhibitor of CsxA Amycolatopsis orientalis
additional information neither castanospermine nor australine are capable of inhibiting the enzyme at a concentration of 1 mM Amycolatopsis orientalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
chitosan + H2O Amycolatopsis orientalis
-
 D-glucosamine + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Amycolatopsis orientalis Q56F26
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl 2-amino-2-deoxy-beta-D-glucopyranoside + H2O
-
 Amycolatopsis orientalis 4-methylumbelliferone + 2-amino-2-deoxy-beta-D-glucopyranose
-
 ?
chitosan + H2O
-
 Amycolatopsis orientalis D-glucosamine + ?
-
 ?

Synonyms

Synonyms Comment Organism
CsxA
-
 Amycolatopsis orientalis
exo-beta-D-glucosaminidase
-
 Amycolatopsis orientalis
exo-chitosanase
-
 Amycolatopsis orientalis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00061
-
 (1S,6S,7R,8R)-6-aminooctahydroindolizine-1,7,8-triol
-
 Amycolatopsis orientalis
0.175
-
 (1R,2R,3R,7S,7aR)-3-(aminomethyl)hexahydro-1H-pyrrolizine-1,2,7-triol
-
 Amycolatopsis orientalis