Literature summary for 3.2.1.143 extracted from

Li, X.; Li, X.; Zhu, Z.; Huang, P.; Zhuang, Z.; Liu, J.; Gao, W.; Liu, Y.; Huang, H.
Poly(ADP-Ribose) glycohydrolase (PARG) silencing suppresses benzo(a)pyrene induced cell transformation (2016), PLoS ONE, 11, e0151172 .

Search for more literature for 3.2.1.143

Application

Application	Comment	Organism
pharmacology	PARG is a potential interventional target to improve the efficacy of cancer chemotherapy	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	poly(ADP-ribose) glycohydrolase (PARG) silencing and generation of PARG-deficient human bronchial epithelial cells. Silencing of PARG significantly reduces the volume and weight of tumors in Balb/c nude mice injected with benzo(a)pyrene (BaP)-induced transformed human bronchial epithelial cells. PARG-silenced shPARG cells show less chromosomal damage than wild-type 16HBE cells. PARG silencing inhibits BaP-induced micronuclei formation. PARG silencing protects cells against BaP-induced cytotoxicity and cytogenetic damage, and inhibits BaP-induced cell transformation by reducing genomic instability in cells. PARG-deficient phenotype, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q86W56	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bronchial epithelial cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PARG	-	Homo sapiens
poly(ADP-ribose) glycohydrolase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	poly(ADP-ribose) glycohydrolase (PARG) silencing suppresses benzo(a)pyrene induced cell transformation. Benzo(a)pyrene (BaP) is a ubiquitously distributed environmental pollutant and known carcinogen, which can induce malignant transformation in cells. PARG silencing dramatically reduces DNA damages, chromosome abnormalities, and micronuclei formations in the PARG-deficient human bronchial epithelial cells compared to the control 16HBE cells. PARG silencing down-regulates cell colony formation induced by BaP, reduces BaP-induced genomic instability, and protects cells from BaP-induced DNA damage	Homo sapiens
physiological function	poly(ADPribose) glycohydrolase (PARG) is the primary enzyme that catalyzes the degradation of poly (ADP-ribose) (PAR), it plays an important role in regulating DNA damage repair and maintaining genomic stability	Homo sapiens

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Release 2023.1 (January 2023)