Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | complete loss of activity, presence of Zn2+ restores the activity | Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | presence of Zn2+ restores the activity lost by incubation with EDTA | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WHS1 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WHS1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + H2O | - |
Mycobacterium tuberculosis | [CysO sulfur-carrier protein]-Gly-NH-CH2-COOH + L-cysteine | - |
? | |
[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + H2O | - |
Mycobacterium tuberculosis H37Rv | [CysO sulfur-carrier protein]-Gly-NH-CH2-COOH + L-cysteine | - |
? | |
[CysO sulfur-carrier protein]-His10-L-Ala-NH-CH2-C(O)-S-L-cysteine + H2O | - |
Mycobacterium tuberculosis | [CysO sulfur-carrier protein]-His-10-L-Ala-NH-CH2-COOH + L-cysteine | - |
? | |
[CysO sulfur-carrier protein]-His10-L-Ala-NH-CH2-C(O)-S-L-cysteine + H2O | - |
Mycobacterium tuberculosis H37Rv | [CysO sulfur-carrier protein]-His-10-L-Ala-NH-CH2-COOH + L-cysteine | - |
? | |
[CysO sulfur-carrier protein]-His10-L-Cys-NH-CH2-C(O)-S-L-cysteine + H2O | - |
Mycobacterium tuberculosis | [CysO sulfur-carrier protein]-His-10-L-Cys-NH-CH2-COOH + L-cysteine | - |
? | |
[CysO sulfur-carrier protein]-His10-L-Cys-NH-CH2-C(O)-S-L-cysteine + H2O | - |
Mycobacterium tuberculosis H37Rv | [CysO sulfur-carrier protein]-His-10-L-Cys-NH-CH2-COOH + L-cysteine | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | sequence contains the JAMM motif | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
CysO-cysteine peptidase | - |
Mycobacterium tuberculosis |
mec | - |
Mycobacterium tuberculosis |
Rv1334 | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
physiological function | in cysteine biosynthesis, cysteine synthase M catalyzes the addition of cysteine to the carboxy terminus of the protein-bound thiocarboxylate to generate a CysO-cysteine adduct. Protease Mec hydrolyzes the CysO-cysteine adduct to release cysteine and regenerate CysO | Mycobacterium tuberculosis |